Autopsy report · NCT02769065

Study of TAK-071 in Healthy Participants and Participants With Mild Cognitive Impairment/Mild Alzheimer Disease and Relative Bioavailability (BA) and Food Effect of TAK-071 in Healthy Participants

“Terminated prematurely as data from cohort no longer needed due to indication change.”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 1 year 1 month before it stopped.
• 179 participants enrolled.
• Results were posted on the registry 2 years after it ended.

Vital statistics

Status

Terminated

Phase

Phase 1

Sponsor

Takeda

Sponsor type

Industry

Conditions

Alzheimer Disease; Healthy Volunteers

Interventions

TAK-071; Donepezil; TAK-071 Placebo; Donepezil Placebo

Participants

179

Sites

1

Countries

United States

Trials that died the same way

• Safety and Pharmacokinetics of Subcutaneous Dose of IMG-007 in Healthy Participants
  “Cohorts 1 and 2 were completed. Cohort 3 was cancelled because it was no longer necessary based on information from another study. No safety concerns were noted.” (70% match in meaning)
• Derazantinib Alone or in Combination With Paclitaxel, Ramucirumab or Atezolizumab in Gastric Adenocarcinoma
  “Terminated prematurely for administrative reasons not related to patient safety.” (63% match in meaning)
• Study of Etanercept in Subjects With Rheumatoid Arthritis Who Have Had an Inadequate Response to Adalimumab or Infliximab Plus Methotrexate
  “This study was prematurely terminated on June 25, 2014 due to lack of enrollment.” (62% match in meaning)
• A Study of De-immunized DI-Leu16-IL2 Administered Subcutaneously in Participants With B-cell NHL
  “Clinical benefit was noted in the earlier portion of the trial; hence, participants were not enrolled in 2 expansion cohorts and the study was terminated early.” (62% match in meaning)
• QUILT-3.031: AMG 337 in Subjects With Advanced or Metastatic Clear Cell Sarcoma
  “Prematurely terminated due to lack of therapeutic effect” (62% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.