Alzheimer Disease

Why trials studying Alzheimer Disease stopped, in this sample of ClinicalTrials.gov.

24 stopped trials with a clear reason; 92% ended for non-scientific reasons.

Trials

• Presence of Anti-RACH Antibodies and Neurocognitive Disorder in Myasthenic or Alzheimers's Patients.
  NCT06523296 · TERMINATED · slow accrual
  “recruitment challenges”
• Toolkit for Experiential Well-beiNg in Dementia (TEND)
  NCT06257563 · WITHDRAWN · funding business
  “We are withdrawing our study due to regulatory requirements from our funding source.”
• Effect of Neuronavigated Theta-Burst Transcranial Magnetic Stimulation (TBS) for Early Alzheimer's Disease
  NCT06524817 · WITHDRAWN · funding business
  “The study was terminated due to funding constraints and resource limitations that made further recruitment and continuation unfeasible.”
• Highlighting the Benefits of Therapeutic Gardens in Alzheimer's Disease by 18F-FDG Cerebral PET /CT
  NCT04514328 · WITHDRAWN · logistics pi
  “the study never opened for pandemic reasons”
• A Phase 2a Study to Investigate REM0046127 in Mild to Moderate Alzheimer's Disease
  NCT05478031 · TERMINATED · slow accrual
  “Due to the event of repeated elevated transaminase levels in one subject - elevated ALT/AST up to 6x ULN in the absence of any other potential underlying cause - we have decided to terminate the study.”
• Lymphatic System Health in Alzheimer's Disease
  NCT04205539 · WITHDRAWN · logistics pi
  “Pending COVID-19 pandemic”
• Recognizing Pain Intensity in Alzheimer's Disease
  NCT04614532 · TERMINATED · slow accrual
  “Reduced recruitment potential for study participants.”
• Study of the Efficacy and Safety of Various Anti-inflammatory Agents in Participants With Mild Cognitive Impairment or Mild Alzheimer's Disease
  NCT04795466 · TERMINATED · funding business
  “Terminated by Sponsor”
• Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study of Oral ASN51 in Healthy Subjects and Subjects With Alzheimer's Disease
  NCT04759365 · TERMINATED · logistics pi
  “Delays with sites, identifying/enrolling patients, impact of COVID, staffing, and duration”
• Safety of SNK01 in Subjects With Alzheimer's Disease (ASK-AD)
  NCT04678453 · TERMINATED · funding business
  “The study was terminated after completing the dose escalation portion of the study. The expansion cohort was not initiated to conduct a global trial based on the approved US IND using a new manufacturing process.”
• The MObile AssessMENT of Behavioral and Psychological Symptoms of Dementia in Amnestic MCI and AD (MOMENT) Study
  NCT04482036 · TERMINATED · funding business
  “The Principle Investigator changed careers and relinquished their NIA funded career development award, which funded the MOMENT Study. Career development awards are not transferable. Thus, the study was terminated prematurely.”
• Florbetaben as an Amyloid Plaque Marker in Elderly Patients With Focal or Disseminated Superficial Hemosiderosis
  NCT02664571 · WITHDRAWN · regulatory
  “experimental drug prohibited by the ANSM (French competent authority)”
• Lack of Decision-making in Patients With Alzheimer's Disease : Functions Involved and the Daily Consequences
  NCT03991624 · TERMINATED · slow accrual
  “Challenges in inclusion”
• Feasibility and Efficacy of Dietary Interventions for Older Adults With Subjective Cognitive Decline
  NCT03585907 · WITHDRAWN · funding business
  “Lack of funding”
• Neuro RX Gamma - Pivotal Phase
  NCT03484143 · SUSPENDED · slow accrual
  “Recruitment has been too slow. We are considering some changes to the protocol.”
• Neurofeedback in Alzheimer's Disease
  NCT03790774 · TERMINATED · logistics pi
  “Due to COVID-19 concerns and restrictions in our at-risk population, interactions were halted.”
• Videofluoroscopic Swallowing Study (VFSS)
  NCT03387267 · TERMINATED · futility
  “Study terminated due to futility”
• Validation and Standardization of a Battery Evaluation of the Socio-emotional Functions in Various Neurological Pathologies
  NCT03052712 · TERMINATED · slow accrual
  “not enough patients”
• Study of TAK-071 in Healthy Participants and Participants With Mild Cognitive Impairment/Mild Alzheimer Disease and Relative Bioavailability (BA) and Food Effect of TAK-071 in Healthy Participants
  NCT02769065 · TERMINATED · funding business
  “Terminated prematurely as data from cohort no longer needed due to indication change.”
• PET Imaging of Subjects Using 124I-PU-AD
  NCT03371420 · TERMINATED · funding business
  “Company has ceased operations”
• LESCOD: "Lewy Body Screening in Cognitive Disorders"
  NCT02263287 · TERMINATED · slow accrual
  “recruitment problems”
• Efficacy and Safety of Curcumin Formulation in Alzheimer's Disease
  NCT01001637 · TERMINATED · funding business
  “lack of support”
• Early Diagnosis of Alzheimer-like Dementia: Benefit of MRI and PET Imaging
  NCT01815112 · TERMINATED · logistics pi
  “Administrative re-organization of the department. Referent physician left the hospital.”
• Evaluation of [123I] AV94 and SPECT in Subjects With Alzheimer Disease in Comparison to Healthy Subjects
  NCT00605059 · TERMINATED · futility
  “Scans showed no visual difference between affected subjects \& healthy volunteers”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.