Autopsy report · NCT01874288

A Study of De-immunized DI-Leu16-IL2 Administered Subcutaneously in Participants With B-cell NHL

“Clinical benefit was noted in the earlier portion of the trial; hence, participants were not enrolled in 2 expansion cohorts and the study was terminated early.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 6 months before it started.
• Ran for about 3 years before it stopped.
• 24 participants enrolled.
• Results were posted on the registry 4 years after it ended.

Vital statistics

Status

Terminated

Phase

Phase 1, Phase 2

Sponsor

Alopexx Oncology, LLC

Sponsor type

Industry

Conditions

B-cell Non-Hodgkin Lymphoma

Interventions

DI-Leu16-IL2

Participants

24

Sites

5

Countries

United States

Trials that died the same way

• Venetoclax and Quizartinib in Treating Patients With FLT3-mutated Recurrent or Refractory Acute Myeloid Leukemia
  “This study was terminated early due to other competing trials, therefore did not go on to the Phase II portion of the study.” (77% match in meaning)
• A Clinical Study to Evaluate the Safety, Tolerability, PK, PD, and Efficacy of KBP-089 in Patients With T2DM
  “The trial was planned to be conducted in 4 cohorts but was terminated after completion of Cohort 2 for strategic reasons due to limited PD effects.” (75% match in meaning)
• Acute Effects Of Donepezil On Brain Perfusion And Memory In Subjects With Cognitive Impairment And Mild Alzheimer's Disease
  “The study was terminated because of slow enrollment. The decision to terminate the trial was not based on any safety or efficacy concerns.” (74% match in meaning)
• Efficacy and Tolerability of Deucravacitinib in the Management of Palmoplantar Pustulosis
  “Terminated early due to lack of expected efficacy. Three participants were enrolled but none completed the study.” (72% match in meaning)
• Endoscopic Full Thickness Resection of Gastric Subepithelial Tumors (FROST)
  “According to study protocol the trial was terminated because the recruitment of trial participants was insufficient.” (72% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.