Autopsy report · NCT02669914

MEDI4736 (Durvalumab) in Patients With Brain Metastasis From Epithelial-derived Tumors

“Low accrual, funding withdrawn by AstraZeneca, and change in clinical practice”

The sponsor’s own words in the registry.

Life of this trial

• Registered 8 months before it started.
• Ran for about 1 year 4 months before it stopped.
• 4 participants enrolled.
• Results were posted on the registry 9 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Washington University School of Medicine

Sponsor type

University, hospital or other

Conditions

Non-Small Cell Lung Cancer; Nonsmall Cell Lung Cancer; Breast Cancer; Cancer of Breast; Cancer of the Breast; Gastroesophageal Cancer

Interventions

MEDI4736

Participants

4

Sites

1

Countries

United States

Trials that died the same way

• Acalabrutinib for GVHD Prophylaxis in Allogeneic Hematopoietic Stem Cell Transplantation in Lymphomas and Leukemia
  “Manufacturer AstraZeneca withdrew the study due to lack of funding” (77% match in meaning)
• Seroquel Alone Versus Seroquel With an SSRI for Depression With Psychotic Symptoms
  “AstraZeneca halted funding; patent expired for Seroquel (Quetiapine) in 2012” (67% match in meaning)
• Bevacizumab vs Dacarbazine in Metastatic Melanoma
  “Lack of financing of the study drug. Not sufficient financial support.” (62% match in meaning)
• Study to Assess Safety and Tolerability of AZD0530 in Combination With Carboplatin and Paclitaxel
  “AstraZeneca has discontinued the development of AZD0530. No new AstraZeneca-sponsored clinical studies will be initiated..” (62% match in meaning)
• Safety and Tolerability Study of AZD4831 in Patients With Heart Failure.
  “A decision was made to stop the study early when AstraZeneca evaluated the available data and it was considered that completing the study would provide limited additional information and unlikely to change the study conclusions.” (60% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.