Autopsy report · NCT00955474

Seroquel Alone Versus Seroquel With an SSRI for Depression With Psychotic Symptoms

“AstraZeneca halted funding; patent expired for Seroquel (Quetiapine) in 2012”

The sponsor’s own words in the registry.

Life of this trial

• Registered 11 months after it had already started.
• Ran for about 4 years 4 months before it stopped.
• 32 participants enrolled.
• Results were posted on the registry 3 years 2 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 4

Sponsor

Massachusetts General Hospital

Sponsor type

University, hospital or other

Conditions

Major Depressive Disorder With Psychotic Features

Interventions

Quetiapine; escitalopram; Sertraline; Citalopram

Participants

32

Sites

1

Countries

United States

Trials that died the same way

• MEDI4736 (Durvalumab) in Patients With Brain Metastasis From Epithelial-derived Tumors
  “Low accrual, funding withdrawn by AstraZeneca, and change in clinical practice” (67% match in meaning)
• Acalabrutinib for GVHD Prophylaxis in Allogeneic Hematopoietic Stem Cell Transplantation in Lymphomas and Leukemia
  “Manufacturer AstraZeneca withdrew the study due to lack of funding” (63% match in meaning)
• Study to Assess Safety and Tolerability of AZD0530 in Combination With Carboplatin and Paclitaxel
  “AstraZeneca has discontinued the development of AZD0530. No new AstraZeneca-sponsored clinical studies will be initiated..” (61% match in meaning)
• A Study of the Safety and Pharmacokinetics of AGS-8M4 Given in Combination With Chemotherapy in Women With Ovarian Cancer
  “Trial was terminated to allow sponsors to evaluate the future development of the drug program” (57% match in meaning)
• Oblimersen Sodium & Combination Chemotherapy in Treating Patients With Newly Diagnosed Diffuse Large B-Cell Lymphoma
  “Manufacturer is no longer making the drug.” (56% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.