Autopsy report · NCT01016054

A Study of the Safety and Pharmacokinetics of AGS-8M4 Given in Combination With Chemotherapy in Women With Ovarian Cancer

“Trial was terminated to allow sponsors to evaluate the future development of the drug program”

The sponsor’s own words in the registry.

Life of this trial

• Registered 1 month after it had already started.
• Ran for about 6 months before it stopped.
• 4 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 1

Sponsor

Astellas Pharma Inc

Sponsor type

Industry

Conditions

Carcinoma; Ovarian Cancer; Ovarian Diseases; Ovarian Neoplasms

Interventions

AGS-8M4; Pegylated liposomal doxorubicin (PLD); gemcitabine; carboplatin

Participants

4

Sites

1

Countries

United States

Trials that died the same way

• Study of Magrolimab Combinations in Patients With Relapsed/Refractory Multiple Myeloma
  “This study was terminated early due to the Sponsor's decision to discontinue development of the investigational drug and close the program.” (82% match in meaning)
• Safety and Efficacy of MAGE-A3/A6 T Cell Receptor Engineered T Cells (KITE-718) in HLA-DPB1*04:01 Positive Adults With Advanced Cancers
  “The study was terminated due to the sponsor's decision to discontinue the clinical trial.” (78% match in meaning)
• Panobinostat/Velcade in Multiple Myeloma
  “This study was terminated because the drug company stopped making the study drug” (77% match in meaning)
• A Phase 2 Study of Intravitreal AVD-104 in Diabetic Macular Edema
  “The trial was stopped early due to insufficient study drug supply and study funding constraints” (76% match in meaning)
• Study to Determine the Safety and Efficacy of INCB018424 in Patients With Polycythemia Vera or Essential Thrombocythemia
  “Termination of the clinical trial by sponsor.” (76% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.