Massachusetts General Hospital

Why trials sponsored by Massachusetts General Hospital stopped, in this sample of ClinicalTrials.gov.

67 stopped trials with a clear reason; 93% ended for non-scientific reasons.

Trials

• Toolkit for Experiential Well-beiNg in Dementia (TEND)
  NCT06257563 · WITHDRAWN · funding business
  “We are withdrawing our study due to regulatory requirements from our funding source.”
• Behavioral Coaching Intervention (Laguna Health) for Patients With Cancer
  NCT06004141 · TERMINATED · funding business
  “Terminated due to withdrawal of funding from Sponsor (Laguna Health)”
• Evaluation of Kisspeptin Stimulated Insulin Secretion With Hyperglycemic Clamp
  NCT05456854 · WITHDRAWN · futility
  “Futility”
• Feasibility, Safety and Utility of Endomicroscopy to Study the Intestines of Unsedated Infants at UVa
  NCT05857488 · TERMINATED · slow accrual
  “A shift occurred in the focus of the research, following the emergence of new scientific knowledge regarding the disease. Hence, study was terminated early and withdrawn by the investigator and no further subjects were enrolled.”
• Personalized Performance Optimization Platform
  NCT06979570 · TERMINATED · funding business
  “The study was terminated early due to loss of funding”
• A Study of the Role of Circulating Tumor DNA in Predicting the Likelihood of Organ Preservation After Clinical Complete Response to Neoadjuvant Therapy for Rectal Cancer
  NCT03749083 · WITHDRAWN · funding business
  “Funding”
• Text-Enabled Ascertainment and Community Linkage for Health
  NCT04058301 · TERMINATED · logistics pi
  “COVID-19”
• EnBrace HR for PMS With Prominent Mood Symptoms or Menstrual Related Mood Disorders
  NCT04123483 · WITHDRAWN · funding business
  “Cancellation of funding contract”
• Study to Assess Sarilumab in Halting Progression of Morphea
  NCT03679845 · WITHDRAWN · slow accrual
  “Difficulty in recruiting patients”
• Waitlist-Control Trial of Smartphone CBT for Obsessive-Compulsive Disorder (OCD)
  NCT03767491 · WITHDRAWN · other
  “Study must be registered under the sponsor instead of the site, so we have created a new posting in the sponsor's account.”
• Waitlist-Control Trial of Smartphone CBT for Major Depressive Disorder (MDD), Withdrawn
  NCT03769350 · WITHDRAWN · other
  “Study must be registered under the sponsor instead of the site, so we have created a new posting in the sponsor's account.”
• Safety and Efficacy of ABI-009 (Nab-rapamycin) in Combination With Pomalidomide and Dexamethasone for Relapsed and Refractory Multiple Myeloma
  NCT03657420 · WITHDRAWN · funding business
  “Funding withdrawn by sponsor”
• Effects of Nitric Oxide on the Endothelium During Hemolysis.
  NCT03748082 · WITHDRAWN · funding business
  “Lack of funding”
• A Pilot Study Of Ga-68-DOTA-TOC Imaging In Participants With Small Bowel Carcinoid Tumors
  NCT03057509 · WITHDRAWN · slow accrual
  “Slow accrual”
• Direct-acting Antiviral Therapy to Prevent HCV Infection for HCV Positive Donor to HCV Negative Recipient Kidney Transplant
  NCT03093740 · WITHDRAWN · regulatory
  “Withdrew IRB application, never approved and no subjects enrolled”
• Transcutaneous Vagus Nerve Stimulation for Motor Recovery After Stroke
  NCT03292159 · TERMINATED · funding business
  “funding not continued”
• Urethral Catheter Immobilization Device to Reduce Catheter-Related Discomfort
  NCT03341468 · WITHDRAWN · logistics pi
  “PI confirmed no subjects consented and stated study not started due to insufficient staffing and once staff on board, the COVID-19 public health emergency occurred.”
• Cardiometabolic Disease and Pulmonary Hypertension
  NCT03349775 · TERMINATED · safety
  “After discussion with the Data Safety Monitoring Board and NIH, the randomized clinical trial involving metformin vs. placebo is terminated due to slow enrollment in the setting of the COVID-19 pandemic.”
• Patient-specific, Effective, and Rational Functional Connectivity Targeting for DBS in OCD
  NCT03244852 · WITHDRAWN · slow accrual
  “Data was analyzed from a previously collected dataset so no new participants were enrolled.”
• Pattern Separation, Brain Derived Neurotrophic Factors, and Mechanisms of Vortioxetine
  NCT02969876 · TERMINATED · slow accrual
  “Site was unable to reach Sponsor recruitment goals.”
• The Effect of Naloxegol on Refractory Constipation in the Intensive Care Unit
  NCT02705378 · WITHDRAWN · logistics pi
  “PI left institution. Protocol never submitted to the IRB, no contract executed only Confidentiality Agreement, and study not done.”
• Reduced Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplant (HSCT) For Lymphoma
  NCT02724904 · WITHDRAWN · logistics pi
  “Drug logistics”
• Orthopaedic Hand and Upper Extremity Data Repository
  NCT03177642 · WITHDRAWN · other
  “The data initially planned to be collected under this protocol was transferred into multiple smaller protocols that do not constitute clinical trials. No data was collected under this protocol.”
• Naloxegol for the Prevention of Constipation in Postoperative Spinal Surgery Patients
  NCT02946580 · TERMINATED · slow accrual
  “Slow recruitment and inability to extend funding.”
• A Study Of Blinatumomab For The Treatment Of Relapsed Or Refractory Indolent Non-Hodgkin Lymphoma
  NCT02811679 · TERMINATED · slow accrual
  “Study closed early due to slow accrual”
• Physiological and Cognitive Biomarkers for Ketamine's Antidepressant Effects
  NCT02669043 · TERMINATED · funding business
  “Funding ended.”
• Maintenance of ANCA Vasculitis Remission by Intermittent Rituximab Dosing
  NCT02749292 · TERMINATED · logistics pi
  “Due to the coronavirus disease 2019 (COVID-19) pandemic and the deleterious impact of rituximab on vaccination efficacy, the trial was concluded before reaching the target enrollment of 200.”
• Effects of Botox in Obstructed Defecation Syndrome
  NCT02160288 · TERMINATED · slow accrual
  “Low recruitment”
• Validation of Aspiration Markers in Intubated Patients
  NCT02598713 · WITHDRAWN · funding business
  “Lack of funding”
• Intranasal Ketamine for Late-Life Depression and Suicidal Ideation
  NCT02295787 · WITHDRAWN · funding business
  “No funding”
• Effect of Guanfacine on Opioid-induced Hyperalgesia (OIH) and Tolerance
  NCT01681264 · TERMINATED · funding business
  “End of NIH funding”
• A Randomized Trial Measuring the Effect of Decision Aids on Patients' Satisfaction, Conflict of Decision-making and Clinical Outcome
  NCT01693094 · SUSPENDED · logistics pi
  “Not adequate number of staff to continue study at the moment.”
• Residual Extensor Lag Approximately 1 Month After Splint or Cast Immobilization of a Mallet Finger
  NCT02210676 · WITHDRAWN · logistics pi
  “Due to the investigator leaving the institution, the study was terminated”
• Video-based Consensus Opinion for Hand and Upper Extremity Problems
  NCT02204605 · WITHDRAWN · logistics pi
  “The principal investigator left the institution.”
• Observational Study of Insulin Resistance and Muscle Wasting After Burn Injury
  NCT02029261 · WITHDRAWN · slow accrual
  “Insufficient recruitment”
• Effect of Pretreatment With Ticagrelor on Residual Thrombus After PCI in Patients Presenting With ACS in Comparison With Delayed Treatment at the Time of PCI: an OCT Study
  NCT01916902 · WITHDRAWN · slow accrual
  “Despite a large number of patients screened, very few met eligibility guidelines.”
• The Effect of Vitamin C on Growth Hormone Secretion
  NCT01537094 · WITHDRAWN · slow accrual
  “Unable to obtain funding to initiate the study. No subjects were enrolled.”
• Cessation of Long-term Opioid Therapy in Chronic Pain Patients
  NCT02132221 · TERMINATED · slow accrual
  “Enrollment too slow given study timeline”
• Genetics of QT Response to Moxifloxacin
  NCT01936480 · TERMINATED · slow accrual
  “Recruitment difficulties”
• Tivozanib + Enzalutamide in Adv Prostate Cancer
  NCT01885949 · TERMINATED · slow accrual
  “Slow accrual”
• The Effects of Vilazodone on Glutamate in the Anterior Cingulate Cortex in Anxious Unipolar Depressives
  NCT02028026 · WITHDRAWN · slow accrual
  “Inability to recruit eligible subjects”
• Adjunctive Isradipine for the Treatment of Bipolar Depression
  NCT01784666 · TERMINATED · slow accrual
  “Lack of Enrollment”
• Prevention of Delirium After Bone Marrow Transplantation
  NCT01700816 · TERMINATED · slow accrual
  “Low incidence of delirium.”
• Potential Use Of Brain Network Activation Analysis to Diagnose Major Depression
  NCT01579942 · TERMINATED · funding business
  “The study was ultimately not funded by the sponsor. No subjects were enrolled.”
• Endoscopic Therapy of Malignant Bile Duct Strictures
  NCT01543607 · TERMINATED · slow accrual
  “Lack of enrollment”
• ON/OFF Stimulation and Impulsivity in Patients With Deep Brain Stimulators
  NCT01506206 · WITHDRAWN · funding business
  “Study was not funded and never enrolled participants.”
• 11C Acetate Imaging Post Prostatectomy
  NCT01602783 · TERMINATED · slow accrual
  “Slow accrual; no further funding”
• Panobinostat With Rituximab for Relapsed/Refractory Diffuse Large B Cell Lymphoma
  NCT01282476 · TERMINATED · slow accrual
  “slow accrual”
• Risks for Insulin Resistance and Metabolic Syndrome Between Major Depressive Disorder (MDD) or MDD With Psychotic Features
  NCT01310140 · TERMINATED · logistics pi
  “PI left Massachusetts General Hospital Inpatient service”
• Clinical Study to Evaluate the Effect of pH on Pain Upon Local Anesthetic Administration.
  NCT01304082 · TERMINATED · slow accrual
  “Insufficient Enrollment”
• Changes in Brown Adipose Tissue Activity In Men Receiving Androgen Deprivation Therapy for Prostate Cancer
  NCT01226888 · TERMINATED · slow accrual
  “Slow accrual”
• Optical Frequency Domain Imaging (OFDI) in Dermatology
  NCT01438047 · WITHDRAWN · funding business
  “The study was closed due to a shift in research priorities and a lack of resources available for the project.”
• Comparison of Xtreme CT and DXA Bone Densitometry
  NCT01199991 · TERMINATED · funding business
  “Limited funding, change in research priorities.”
• Study of Functional Microarray-Facilitated Lidocaine Liposomal Cream Absorption for Cutaneous Anesthesia in Volunteers
  NCT00387296 · WITHDRAWN · logistics pi
  “Funding nonavailability and principal investigator move”
• Omega-3 Fatty Acids Monotherapy in Children and Adolescents With Autism Spectrum Disorders
  NCT01248130 · TERMINATED · logistics pi
  “Due to a change in the research priorities of the principal investigator in combination with low subject interest.”
• Early Detection and Intervention for Mild and Moderate Lymphedema in Patients Treated for Breast Cancer
  NCT00959985 · TERMINATED · slow accrual
  “low accrual”
• A Study to Examine the Safety and Efficacy of Drospirenone and Ethinyl Estradiol (YAZ) Versus Placebo In HS
  NCT00722800 · TERMINATED · slow accrual
  “Poor recruitment”
• Seroquel Alone Versus Seroquel With an SSRI for Depression With Psychotic Symptoms
  NCT00955474 · TERMINATED · funding business
  “AstraZeneca halted funding; patent expired for Seroquel (Quetiapine) in 2012”
• MRI Scans in Evaluating the Effects of Radiation Therapy and Chemotherapy in Patients With Newly Diagnosed Glioblastoma Multiforme or Anaplastic Glioma
  NCT00756106 · TERMINATED · funding business
  “Funding ended”
• Secretin Enhanced MRCP for Evaluation of Pancreatic Duct in Pediatric Population
  NCT00621283 · TERMINATED · slow accrual
  “Poor patient enrollment due to logistical issues”
• Invega (Paliperidone) for the Treatment of Mania in Children and Adolescents Ages 6-17 With Bipolar Disorder
  NCT00592358 · TERMINATED · slow accrual
  “Slow enrollment.”
• Intermittent Letrozole Therapy in Postmenopausal Women With Metastatic Breast Cancer
  NCT00549822 · TERMINATED · slow accrual
  “Slow Accrual”
• Intra-Operative Dural Brachytherapy With Yttrium-90 Plaque Applicators
  NCT00706485 · TERMINATED · regulatory
  “New device for dural plaque irradiation was approved by FDA.”
• Effects of TNF-alpha Antagonism (Etanercept) in Patients With the Metabolic Syndrome and Psoriasis
  NCT00477191 · TERMINATED · slow accrual
  “Difficulty in recruitment.”
• Effect of Increasing Testosterone on Insulin Sensitivity in Men With the Metabolic Syndrome
  NCT00438321 · TERMINATED · logistics pi
  “PI relocated”
• Ziprasidone for the Treatment of Generalized Anxiety in Patients With Bipolar Disorder
  NCT00374543 · TERMINATED · slow accrual
  “Recruitment goal could not be achieved”
• Glutamine Enriched Total Parenteral Feeding and Proline Metabolism in Severely Burned Patients
  NCT00217035 · WITHDRAWN · slow accrual
  “State of Mass. tightened regulations for making intravenous solutions for research subjects. Study was withdrawn and no participants were enrolled.”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.