Washington University School of Medicine

Why trials sponsored by Washington University School of Medicine stopped, in this sample of ClinicalTrials.gov.

60 stopped trials with a clear reason; 88% ended for non-scientific reasons.

Trials

• The Perinatal Synergistic Multi-component Intervention to alLeviate dEpressive Symptoms. A Case Series
  NCT06048263 · WITHDRAWN · logistics pi
  “PI is leaving the university”
• Testing the Feasibility and Acceptability of Social Media and Digital Therapeutics to Decrease Vaping Behaviors
  NCT05994209 · TERMINATED · slow accrual
  “Due to low recruitment”
• TruGraf Liver Gene Expression Serial Test
  NCT06061341 · TERMINATED · funding business
  “Funding discontinued”
• Neoadjuvant SGLT2 Inhibition in Localized Prostate Cancer
  NCT04887935 · TERMINATED · slow accrual
  “Low accrual”
• Providing Cancer Care Closer to Home for Patients With Multiple Myeloma
  NCT05971056 · TERMINATED · funding business
  “Insufficient funding”
• Behavioral Plant-Based Dietary Intervention in Latinos
  NCT05444595 · WITHDRAWN · logistics pi
  “Administrative reasons”
• Online Peri-operative Education Program for Patients Undergoing Major Head & Neck Surgery
  NCT05954676 · WITHDRAWN · slow accrual
  “Zero accruals”
• PET Synaptogenesis After Psilocybin In DEpression Recovery
  NCT05601648 · WITHDRAWN · futility
  “Due to negative results in similar trials using 11C-UCB-J”
• Chemotherapy in Patients With Relapsed Small Cell Lung Cancer in Combination With Allopurinol and MycoPhenolate (CLAMP Trial)
  NCT05049863 · TERMINATED · futility
  “Futility”
• Family-Based Behavioral Treatment for Childhood Survivors of Acute Lymphoblastic Leukemia
  NCT05410574 · TERMINATED · logistics pi
  “Insufficient staff”
• Role of Proton Pump Inhibitors on the Postoperative Course Following Pancreaticoduodenectomy
  NCT05251233 · TERMINATED · logistics pi
  “Investigator and study team chose to end study early.”
• Isatuximab, Velcade, and Dexamethasone in Patients With Multiple Myeloma and Severe KIDNEY Disease
  NCT04912427 · TERMINATED · slow accrual
  “Low accrual”
• Baricitinib for the Treatment of Ocular Mucous Membrane Pemphigoid
  NCT05263505 · TERMINATED · funding business
  “Sponsor”
• Immune Checkpoint Blockade Therapy Using 18F-FLT PET/CT
  NCT04271436 · WITHDRAWN · slow accrual
  “Low accrual”
• Implementation of the Families Accelerating Cascade Testing Toolkit (FACTT) for Hereditary Breast and Ovarian Cancer and Lynch Syndrome
  NCT04508764 · TERMINATED · funding business
  “Loss of funding and slow enrollment”
• Lattice Stereotactic Body Radiation Therapy (Lattice SBRT) for Localized Unresectable or Metastatic Conventional Type Chondrosarcoma
  NCT04098887 · WITHDRAWN · funding business
  “Investigator decided to not go forward with the study.”
• Suubi4Cancer: Improving Access to Pediatric Cancer Services and Treatment Adherence Among Children Living With HIV/AIDS
  NCT03916783 · WITHDRAWN · slow accrual
  “We implemented Aims 1 and 2, but did not have a sufficient sample size to carry out the clinical trial portion”
• Scalp Block: Hemodynamic Stability and Patient Comfort In Craniotomy Patients
  NCT03177252 · WITHDRAWN · funding business
  “Investigator decided not to go forward with the trial.”
• Core Warming of COVID-19 Patients
  NCT04426344 · WITHDRAWN · funding business
  “Internal decision”
• WU 345: Immune Responses to Adjuvanted and Non-adjuvanted Seasonal Influenza Vaccines in the Lymphoid Tissues.
  NCT07386509 · TERMINATED · safety
  “COVID pandemic No participant experiences (benefits, adverse events/adverse reactions)to report. There have been no safety concerns in either participant. No minor deviations to report”
• Diabetes/ Endocrine Surveillance in SDS
  NCT04275479 · TERMINATED · funding business
  “funding stopped”
• Dietary Protein and Monocyte/Macrophage Mammalian Target of Rapamycin (mTOR) Signaling
  NCT03946774 · TERMINATED · logistics pi
  “Temporarily paused due to COVID-19 and expected to resume. This is not a suspension of IRB approval. PI has left the institution.”
• Middle Meningeal Artery Embolization for Chronic Subdural Hematoma
  NCT04065113 · WITHDRAWN · regulatory
  “due to reason 3 in the protocol- any new information becomes available during the trial that necessitates stopping the trial. New information became available with device no longer being investigational.”
• Abemaciclib + Nivolumab in Patients With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed or Recurred Within Six Months After Platinum-based Chemotherapy
  NCT03655444 · TERMINATED · funding business
  “Provider of drug decided to discontinue study.”
• TraceIT Tissue Marker to Mark the Primary Resection Bed Margins of Oropharyngeal Cancers
  NCT03713021 · TERMINATED · logistics pi
  “Equipment unavailable”
• Personalized Therapeutic Anti-tumor Vaccine With Pembrolizumab and Standard of Care Chemotherapy in Squamous Non-Small Cell Lung Cancer and Extensive Stage Small Cell Lung Cancer
  NCT03166254 · WITHDRAWN · funding business
  “Lost funding”
• Pulsed Abraxane and Radiotherapy for Improving and Maintaining Ambulation After Cancer-Related Cord Compression
  NCT03655080 · TERMINATED · funding business
  “Pharmaceutical company decided to close study”
• Personalized Tumor Vaccine Strategy and PD-1 Blockade in Patients With Follicular Lymphoma
  NCT03121677 · TERMINATED · manufacturing supply
  “Vaccine manufacturing has been suspended”
• Glucose Uptake in Metabolic Tissues After Bariatric Surgery
  NCT03563885 · TERMINATED · funding business
  “Financial and Method issues suggesting that study is not feasible.”
• Proton Beam Therapy in the Treatment of Esophageal Cancer
  NCT03482791 · TERMINATED · regulatory
  “The study is no longer relevant to have open to ensure insurance approval for this patient population”
• Ultrasound and Photoacoustic Imaging for Cervical Cancer
  NCT03318107 · TERMINATED · slow accrual
  “Low accrual”
• Prophylactic Antibiotics Prior to Embryo Transfer (PAPET): RCT
  NCT03386227 · TERMINATED · slow accrual
  “The study was prematurely stopped due to extremely low recruitment and lack of feasibility to continue.”
• Neoadjuvant Avelumab and Hypofractionated Proton Radiation Therapy Followed by Surgery for Recurrent Radiation-refractory Meningioma
  NCT03267836 · TERMINATED · funding business
  “Study sponsor wanted to terminate enrollment.”
• Providing Patients Realistic Expectations of Postoperative Pain
  NCT03434847 · TERMINATED · logistics pi
  “CMS questions to assess patient satisfaction of pain control were removed from the HCAHPS survey, leaving the study without intervention assessment.”
• Pacritinib in Combination With Low Dose Decitabine in Intermediate-High Risk Myelofibrosis or Myeloproliferative Neoplasm (MPN)/Myelodysplastic Syndrome (MDS)
  NCT02564536 · WITHDRAWN · funding business
  “Lack of funding following full FDA clinical hold”
• Daily Online Adaptation Versus Localization for MRI-Guided SBRT for Unresectable Primary or Oligometastatic Abdominal Malignancies
  NCT02950025 · TERMINATED · slow accrual
  “Low accrual”
• 18F-FLT PET Imaging in Patients With Advanced Melanoma
  NCT02891616 · TERMINATED · slow accrual
  “Low accrual rate”
• Video Capsule Endoscopy Versus Colonoscopy in Patients With Melena and Negative Upper Endoscopy
  NCT02609100 · TERMINATED · slow accrual
  “Poor enrollment”
• Tosedostat With Capecitabine in Patients With Metastatic Pancreatic Adenocarcinoma
  NCT02352831 · TERMINATED · funding business
  “Insufficient funding and drug supply from manufacturer”
• Thromboelastography Transfusion Protocol for Pediatric Neuromuscular Scoliosis Surgery
  NCT02670798 · TERMINATED · funding business
  “Expiration of funding”
• Comparing Ketamine and Morphine in the Treatment of Acute Fracture Pain
  NCT02430818 · TERMINATED · slow accrual
  “were not able to enroll patients to a satisfactory level”
• Cytokine-induced Memory-like NK Cells in Patients With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)
  NCT01898793 · TERMINATED · funding business
  “Insufficient funding/staff”
• Cryoablation, Radiofrequency Ablation, or Microwave Ablation in Treating Patients With Metastatic Sarcoma Stable on Chemotherapy
  NCT01986829 · TERMINATED · slow accrual
  “Slow accrual”
• Cap Assisted Balloon Enteroscopy Versus Conventional Balloon Enteroscopy In The Evaluation Of Obscure Gastrointestinal Bleeding: A Randomized Controlled Trial
  NCT02315404 · TERMINATED · slow accrual
  “Poor Enrollment”
• SOD1 Kinetics Measurements in ALS Patients
  NCT03449212 · SUSPENDED · logistics pi
  “COVID-19 pandemic”
• Total vs. Reverse Shoulder Replacement: Pain Relief Two Years After Surgery
  NCT01884077 · TERMINATED · slow accrual
  “slow recruitment and poor follow up”
• Response to Influenza Vaccine in Patients With Non-Hematologic Malignancies Receiving Chemotherapy
  NCT01695733 · TERMINATED · funding business
  “no longer had funding to continue”
• The Role Of Empiric Dilation In Patients With Dysphagia With Normal Endoscopy
  NCT01444066 · TERMINATED · slow accrual
  “poor recruitment”
• Task-Based Functional MRI (fMRI) in Patients With Severely Bothersome Tinnitus
  NCT01172262 · WITHDRAWN · funding business
  “Study did not recieve funding, currenlty undergoing protocol revision.”
• Efficacy Study of Femoral Nerve Block in Children With a Femur Fracture
  NCT01294098 · TERMINATED · slow accrual
  “Patients were not willing to be randomized and therefore recruitment could not continue.”
• Effectiveness in Head and Neck Cancer Detection Using Positron Emission Tomography (PET) Insert Device
  NCT01133262 · WITHDRAWN · other
  “Feasibility/pilot study of 5 subjects registration not required”
• Metabolic Effects of Antipsychotic Substitution in Children
  NCT00910780 · WITHDRAWN · funding business
  “Study was not funded.”
• Skin and Blood Research Samples From Healthy Volunteers and Patients With Hematologic Diseases
  NCT00840567 · TERMINATED · funding business
  “Key samples protocols will be provided by a collaborator and we were not able to produce IPS lines from human fibroblasts.”
• Irritable Bowel Syndrome (IBS) Functional Magnetic Resonance Imaging (fMRI) With Desipramine
  NCT00880594 · TERMINATED · logistics pi
  “Due to changes in trial personnel (co-investigator and research coordinator leaving the institution).”
• Feasibility and Functionality of fPAM Imaging in Melanoma
  NCT00776945 · TERMINATED · funding business
  “no funding”
• The Use of Sensory or Motor Cues Using Electrical Stimulation to Reduce Gait Freezing in Patients With Parkinson Disease
  NCT00762814 · TERMINATED · funding business
  “There was no funding for the device to be used in the study.”
• PET/CT Study in the Diagnosis of Coronary Plaque
  NCT00850473 · TERMINATED · logistics pi
  “Sub-investigator left the university”
• A Phase II Study of Surgical Debulking With Peritonectomy and Biweekly Intraperitoneal 5FU With Systemic Oxaliplatin/5FU/Leucovorin in Patients With Pseudomyxoma Peritonei or Peritoneal Carcinomatosis
  NCT00352755 · TERMINATED · other
  “after interim analysis it was determined that the risks were too great in comparision to the results”
• PTK/ZK as Post Transplant Maintenance Therapy in Patients With Multiple Myeloma
  NCT00240162 · TERMINATED · safety
  “investigator letter from drug manufacturer stating animal studies showed increased risk of cancer which was an unknown adverse event”
• Montelukast Added to Standard Therapy for Acute Asthma in Children Age 6-14 Years
  NCT00353184 · TERMINATED · futility
  “Results of the interim analysis suggested no significant diff between study groups.”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.