Breast Cancer

Why trials studying Breast Cancer stopped, in this sample of ClinicalTrials.gov.

130 stopped trials with a clear reason; 92% ended for non-scientific reasons.

Reason	Trials	Share
slow accrual	65	50%
funding business	33	25%
logistics pi	17	13%
other	5	4%
safety	4	3%
manufacturing supply	4	3%
futility	1	1%
regulatory	1	1%

Trials

Showing the 100 most recent of 130 trials.

TNBC Gut Microbiota During Neoadjuvant Treatment
NCT06610097 · WITHDRAWN · slow accrual
“no patients were able to be enrolled”
Non-Viral TCR Gene Therapy
NCT04102436 · WITHDRAWN · manufacturing supply
“Difficulty with availability of GLP-grade reagents for manufacturing.”
Trastuzumab-deruxtecan in Patients With Triple-negative Metastatic HER2-Low Breast Cancer: Real-world Experience in Brazil
NCT06231693 · TERMINATED · funding business
“The study was stopped due to a realignment of strategic priorities”
Characterization and Kinetic of Chemotherapy-induced Cardiovascular Toxicity in Breast Cancer
NCT05803889 · TERMINATED · logistics pi
“The PROTECT-COEUR study had to be stopped primarily due to logistical constraints.”
A Study of Contrast-Enhanced Mammography (CEM) Scans in People With Breast Cancer
NCT05990478 · WITHDRAWN · slow accrual
“Challenges to participant accrual”
What is Optimal Post-operative Prophylactic Therapy in Irradiated Breasts Undergoing Repeat Surgery
NCT05823467 · TERMINATED · logistics pi
“Logistical Issues”
Comparison of CE-DBT and MRI in Patients With Known Breast Lesions
NCT05754749 · TERMINATED · funding business
“Funding unavailable”
SMART-ER: Symptom Monitoring With Patient-reported Outcomes
NCT05560685 · TERMINATED · funding business
“Loss of funding”
A Study of AC682 In Chinese Patients With ER+/HER2- Locally Advanced or Metastatic Breast Cancer
NCT05489679 · TERMINATED · funding business
“Voluntarily terminate the study since the sponsor's development strategy was adjusted.”
Mastectomy Flap Temperature Study
NCT05395936 · TERMINATED · slow accrual
“low accruals”
Study of NUV-422 in Combination With Fulvestrant in Patients With HR+HER2- aBC
NCT05191004 · WITHDRAWN · funding business
“Sponsor decision”
Impact of Video Information Support on Preoperative Anxiety in Breast Cancer Surgery
NCT05350527 · TERMINATED · manufacturing supply
“The software used for the collection of the primary endpoint is no longer available.”
FT536 Monotherapy and in Combination With Monoclonal Antibodies in Advanced Solid Tumors
NCT05395052 · TERMINATED · funding business
“This study was terminated by the Sponsor.”
TAP vs QL for Postoperative Analgesia After DIEP Free Flap Breast Reconstruction
NCT05301595 · WITHDRAWN · logistics pi
“Study was never started as PI moved to another city”
Therapeutic Cancer Vaccine (AST-301, pNGVL3-hICD) in Patients With Breast Cancer
NCT05163223 · TERMINATED · slow accrual
“Difficulty in recruiting patients”
GM1 Prophylaxis for Post-chemotherapy Cognitive Impairment in Patients With Early Operable Breast Cancer
NCT05239663 · TERMINATED · slow accrual
“Difficulty accruing subjects the study accrual was closed”
Axillary Lymph Node Tattoo Marking Study
NCT04947917 · TERMINATED · funding business
“Institutional standard of care regarding axillary management changed. Decision was made to close the study early.”
A Study of AC682 for the Treatment of Locally Advanced or Metastatic ER+ Breast Cancer
NCT05080842 · TERMINATED · funding business
“Voluntarily terminate the study since the sponsor's development strategy was adjusted.”
A Safety and Tolerability Study of NC762 in Subjects With Advanced or Metastatic Solid Tumors
NCT04875806 · TERMINATED · funding business
“Due to the limited activity in Phase 1, NextCure decided to discontinue development of the anti-B7-H4 antibody monotherapy trial (NC762-01) to move forward with a prioritized B7-H4 ADC program.”
Investigating Atezolizumab in Newly Diagnosed ER Positive Breast Cancer Patients According to Their AdipOsity
NCT04630210 · WITHDRAWN · logistics pi
“Insufficient resources”
Breast Cancer and Resistance Exercise Program
NCT04562233 · TERMINATED · logistics pi
“PI left”
A Phase 1a/1b FIH Study of PY159 and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors
NCT04682431 · TERMINATED · funding business
“Sponsor business decision.”
A Study of PY314 in Subjects With Advanced Solid Tumors
NCT04691375 · TERMINATED · funding business
“Sponsor business decision.”
Study to Assess the Impact of Personalized Coaching on the Time Period and Quality of Return to Work After Breast Cancer
NCT04469205 · TERMINATED · slow accrual
“insufficient recruiting”
Study of CYH33 in Combination With Olaparib an Oral PARP Inhibitor in Patients With Advanced Solid Tumors.
NCT04586335 · TERMINATED · funding business
“Business decision”
Motivational Enhancement Therapy to Improve Adherence to Aromatase Inhibitors
NCT02883361 · WITHDRAWN · funding business
“Our team decided to conduct more preliminary work on understanding AI adherence to support the optimal development of a randomized controlled trial before proceeding with the trial.”
Proton Accelerated Partial Breast Irradiation
NCT03940248 · WITHDRAWN · slow accrual
“Due to insurance non-payment, no subjects were enrolled.”
Real-time Intraoperative Breast Cancer Visualization for Margin Assessment
NCT02807597 · TERMINATED · slow accrual
“Before LS301's licensing and reformulation, 9 patients received LS301-HSA (Phase 1a) , but since no patients were recruited (in Phase 1b) before the product expired, this study has been terminated.”
Phase 2 Window Study of SAR439859 (Amcenestrant) Versus Letrozole in Post-menopausal Patients With ER+, HER2- Pre-operative Post-menopausal Primary Breast Cancer
NCT04191382 · TERMINATED · funding business
“early discontinuation based on strategic sponsor decision not driven by any safety concerns”
Evaluation of a Novel Axillary Lymph Node Ink Localization Technique: A Feasibility Study
NCT04136496 · WITHDRAWN · logistics pi
“The study was never activated / began due to hospital staff and resources being re-allocated to support the demands of the Covid-19 global pandemic.”
A Study of Poziotinib in Patients With Epidermal Growth Factor Receptor (EGFR) or Human Epidermal Growth Factor Receptor 2 (HER2) Activating Mutations in Advanced Malignancies
NCT04172597 · TERMINATED · funding business
“Strategic business decision (unrelated to safety)”
Focused Ultrasound Ablation and PD-1 Antibody Blockade in Advanced Solid Tumors
NCT04116320 · TERMINATED · slow accrual
“Unable to enroll enough patients to complete targeted enrollment in a reasonable time.”
Evaluate RCN3028 in Treatment of Drug-Induced VMS in Breast Cancer
NCT06161792 · TERMINATED · slow accrual
“Difficulty in recruiting breast cancer patients, leading to a slow rate of case enrollment.”
Photoacoustic Lymph Node Imaging
NCT03931655 · TERMINATED · logistics pi
“There have been multiple issues getting the device repaired and then in working order. The PI's have decided to terminate the study. The termination request has been filed with the institution's IRB.”
Surgical and Patient Reported Outcomes of Robotic Nipple-Sparing Mastectomy
NCT04151368 · SUSPENDED · logistics pi
“Recruitment has been temporarily suspended since the start of the pandemic due to the need for travel for this study. Will resume when appropriate.”
Acute Post-Radiation Hyperbaric Oxygen (HBO2) for Breast Cancer Patients Who Have Recently Completed Radiation Therapy
NCT03916068 · TERMINATED · slow accrual
“Insufficient enrollment”
HeartPhone Cancer Survivors Trial 2019
NCT03953326 · TERMINATED · futility
“Futility in recruitment”
DWIBS-MRI: An Adjunct to the Traditional Diagnostic Breast Imaging Evaluation
NCT04491864 · TERMINATED · funding business
“Further funding was not approved for this study”
Speeding Recovery From Pain and Opioid Use
NCT03388814 · WITHDRAWN · funding business
“Lack of Funding”
A Study of Poziotinib in Combination With T-DM1 in HER2-Positive Breast Cancer
NCT03429101 · TERMINATED · safety
“Dose limiting toxicity”
Optimizing the Management of Patients With Oral Therapy
NCT03623490 · TERMINATED · slow accrual
“Following an insufficient recruitment, the sponsor decided to halt prematurely inclusions”
Efficacy of Cardio-Oncology Rehabilitation Exercise for Women With Breast Cancer and Treatment Related Cardiotoxicity
NCT03089502 · TERMINATED · slow accrual
“Limited recruitment”
Pharmacodynamic Biomarkers of Standard Anti-microtubule Drugs as Assessed by Early Tumor Biopsy
NCT03393741 · TERMINATED · slow accrual
“slow accrual”
Trial to Compare the Efficacy and Safety of Pegfilgrastim Biosimilar in Subjects With High Risk Stage Breast Cancer Receiving Chemotherapy
NCT02768714 · WITHDRAWN · funding business
“Strategic changes regarding the product development”
A Clinical Trial Evaluating the Safety and Clinical Activity of Radioiodide (131I-) as a Novel Targeted Therapy for Metastatic Breast Cancer That Overexpresses Functional Na/I Symporter
NCT02988648 · WITHDRAWN · slow accrual
“The study was withdrawn due to lack of enrollment.”
Anti-EGFR-immunoliposomes Loaded With Doxorubicin in Patients With Advanced Triple Negative EGFR Positive Breast Cancer
NCT02833766 · TERMINATED · other
“the trial was prematurely terminated as per SAKK board decision from 14th of November 2020. The trial is to be terminated after primary endpoint is reached.”
Examination of Breast Cancer Cells of Pre-menopausal and Post-menopausal Women Before and After Exposure to Tamoxifen or Fulvestrant.
NCT02936206 · TERMINATED · slow accrual
“low accrual rate”
Multicentre Study to Determine the Feasibility of Using an Integrated Consent Model to Compare Three Standard of Care Regimens for The Treatment of Triple-Negative Breast Cancer in the Neoadjuvant/Adjuvant Setting (REaCT-TNBC)
NCT02688803 · TERMINATED · slow accrual
“The study did not meet the pilot feasibility endpoints and was formally closed to accrual prematurely on February 8, 2017.”
Does the Wording of Text Message Reminders Improve Uptake in Breast Screening?
NCT02872363 · TERMINATED · logistics pi
“The screening service moved to a pan-London service and the trial was not able to be continued.”
Rebastinib Plus Antitubulin Therapy With Paclitaxel or Eribulin in Metastatic Breast Cancer
NCT02824575 · TERMINATED · funding business
“Unfortunately, Deciphera management decided to not move forward with the rebastinib program and are terminating early.”
Dose Escalation Study of HBI-8000 in Combination With Paclitaxel and Trastuzumab in Women With Advanced or Metastatic HER2+ Breast Cancer
NCT02569489 · WITHDRAWN · other
“Reconsideration of Study Design; plan for alternative protocol”
Addition of Aromatase at the Navelbine in Pretreated Metastatic Breast Cancer.
NCT02585388 · TERMINATED · safety
“Treatment toxicity”
Clinical Research of 18F-Alfatide Ⅱ PET/CT in Breast Cancer
NCT02582801 · TERMINATED · logistics pi
“The cyclotron in our hospital has a serious malfunction and can not be repaired. It will take a long time to purchase and install the new cyclotron.”
Metformin for Reduction of Paclitaxel-Related Neuropathy in Patients With Breast Cancer
NCT02360059 · TERMINATED · slow accrual
“Low Accrual”
Measuring the Effect of Radiation Therapy on Patient Activity Levels
NCT02694380 · TERMINATED · slow accrual
“Low accrual”
Nintedanib For HER2-Negative Metastatic Inflammatory Breast Cancer (MIBC)
NCT02389764 · TERMINATED · slow accrual
“Slow Accrual”
GCC 1366: Anti-Proliferative Response to NeoAdjuvant AIs in Overweight and Obese Patients
NCT02095184 · TERMINATED · slow accrual
“This study was terminated due to slow accrual, and this due to the changing practice patterns, and difficulties with insurance coverage for some of the study related tests, such as OncotypeDx.”
Efficacy of the Use of Refrigerant Helmet to Prevent Alopecia in Patients Treated With Eribulin for Breast Cancer
NCT02863146 · TERMINATED · slow accrual
“Lack of enrollment”
CyberKnife Stereotactic Accelerated Partial Breast Irradiation (SAPBI)
NCT02365714 · TERMINATED · slow accrual
“Slow accrual”
A Study of GDC-0810 Single Agent or in Combination With Palbociclib and/or a Luteinizing Hormone-Releasing Hormone (LHRH) Agonist in Women With Locally Advanced or Metastatic Estrogen Receptor Positive Breast Cancer
NCT01823835 · TERMINATED · funding business
“The Sponsor decided to halt the development of GDC-0810, but not due to any safety concerns.”
Neoadj ph 2 AI Plus Everolimus in Postmenopausal Women w/ ER Pos/HER2 Neg, Low Risk Score
NCT02236572 · TERMINATED · slow accrual
“Phase 2 of recruitment was contingent on 5 of 15 patients responding, which did not occur.”
Comparison of Contrast-enhanced Spectral Mammography (CESM) to MRI in Screening High Risk Women for Breast Cancer
NCT02275871 · TERMINATED · funding business
“Didn't have funding to support the study design”
Automated Breast Ultrasound and Digital Breast Tomosynthesis Screening Compared to Full Field Digital Mammography in Women With Dense Breasts
NCT02042456 · TERMINATED · funding business
“Change in study staff at the site, change in Sponsor direction”
Mobile Phone Multimedia Messaging Intervention for Breast Cancer Screening
NCT01972048 · WITHDRAWN · logistics pi
“PI Left University”
Contrast Enhanced Ultrasound and Shear Wave Elastography in Measuring Response in Patients With Breast Cancer Receiving Chemotherapy Before Surgery
NCT02067884 · TERMINATED · slow accrual
“Slow accrual”
A Pilot/Phase II Study of Gamma Knife Radiosurgery for Brain Metastases Using 3Tesla MRI and Rational Dose Selection
NCT02005614 · TERMINATED · slow accrual
“Unable to recruit patients.”
Placebo-controlled Trial With Vitamin D to Prevent Worsening/Relieve Aromatase Inhibitor-induced Musculoskeletal Symptoms in Breast Cancer Patients
NCT01809171 · TERMINATED · slow accrual
“Inclusion problems”
An Open-Label Study of a Novel JAK-inhibitor, INCB047986, Given in Patients With Advanced Malignancies
NCT01929941 · TERMINATED · funding business
“Business decision.”
Anti-Tumor Immunity Induced by Cryoablation of Invasive Breast Cancers
NCT01856036 · TERMINATED · logistics pi
“PI left institute and contacted IRB to close study.”
Phase 2 Trial of AEZS-108 in Chemotherapy Refractory in Triple Negative Breast Cancer
NCT01698281 · TERMINATED · slow accrual
“Poor recruitment”
Microwave Ablation of Breast Tumors
NCT04828044 · WITHDRAWN · funding business
“Lack of sufficient funding”
Ovarian Reserve in Premenopausal Breast Cancer
NCT01726322 · TERMINATED · funding business
“As per the HRBs new funding model, HRBs investment will not support costs associated with routine patient care or translational studies, biobanks, patient registries and questionnaires. Therefore, a decision was made to cease further study follow up.”
A DB Randomized Study of R1 and R2 WaterJel / AloeVera Jell in Prevention of Radiation Dermatitis in Breast Cancer
NCT01597921 · TERMINATED · safety
“The study was stopped due to unbalanced side effects”
Cryoablation for Invasive Breast Carcinoma Following Neoadjuvant Therapy
NCT01388777 · TERMINATED · slow accrual
“Early termination leading to small number of subjects analyzed”
The Effect of Melatonin on Depression, Anxiety, Cognitive Function and Sleep Disturbances in Breast Cancer Patients
NCT01355523 · TERMINATED · slow accrual
“Inclusion rate not as expected. Not financially possible to involve other centres.”
Exploratory, Phase I,Open Label,Non-randomized Study of [F18]CP-18 PET in Normal and Breast Cancer Subjects
NCT01362712 · TERMINATED · slow accrual
“Unable to enroll breast cancer patients with current I/E criteria.”
Prospective Analysis of Changes in Background Parenchymal Enhancement (BPE) and Amount of Fibroglandular Tissue on Breast MRI
NCT01297231 · WITHDRAWN · funding business
“Lack of funding”
Safety, Tolerability, and Efficacy Study in Subjects With Advanced or Metastatic Breast Cancer
NCT01199367 · TERMINATED · slow accrual
“The results of the dose escalation phase did not identify a well-tolerated dose that would permit further study in Phase 2.”
PET/CT Evaluation of Treatment Response in Breast Cancer
NCT01222416 · TERMINATED · slow accrual
“Slow accrual”
A Study of The Safety Profile of First-line Avastin (Bevacizumab) in Combination With Paclitaxel in Patients With Locally Recurrent or Metastatic Her2-negative Breast Cancer (AVATAX)
NCT01156961 · WITHDRAWN · logistics pi
“Absence of patient's recruitment in the study due to administrative reasons”
Re-expression of ER in Triple Negative Breast Cancers
NCT01194908 · TERMINATED · slow accrual
“Slow accrual”
ELBA: Exemestane and Lapatinib in Advanced Breast Cancer
NCT01005641 · WITHDRAWN · logistics pi
“Study not started for administrative reasons”
Metformin Hydrochloride in Treating Women With Stage I or Stage II Breast Cancer That Can Be Removed By Surgery
NCT00984490 · TERMINATED · slow accrual
“slow accrual”
Early Detection and Intervention for Mild and Moderate Lymphedema in Patients Treated for Breast Cancer
NCT00959985 · TERMINATED · slow accrual
“low accrual”
Efficacy and Safety of DLBS1425 in Subjects With Advanced/Metastatic Breast Cancer
NCT01006785 · TERMINATED · slow accrual
“The study was terminated due to difficulty of find eligible subjects”
Neoadjuvant Treatment of Docetaxel, Anthracycline and Cyclophosphamide (TAC) Versus Docetaxel and Cyclophosphamide (TC) in Triple-Negative or Her2 Positive Breast Cancer
NCT00912444 · TERMINATED · other
“TAC treatment was associated with better survial outcome compared with TC treatment, we terminated recruiting and waiting for longer follow up period.”
Dendritic Cell Based Therapy for Breast Cancer Patients
NCT00935558 · WITHDRAWN · slow accrual
“no patients enrolled”
Breast Magnetic Resonance Imaging (MRI) Screening After Mantle Radiation Therapy
NCT00925405 · TERMINATED · slow accrual
“Low accrual”
Axillary Lymph Node Preservation Surgery in Reducing Lymphedema in Patients With Breast Cancer
NCT00932035 · TERMINATED · logistics pi
“Loss of principal investigator”
Trial of RAD001 in Triple Negative Metastatic Breast Cancer
NCT00827567 · TERMINATED · slow accrual
“Slow accrual”
Ixabepilone and Hydroxychloroquine in Treating Patients With Metastatic Breast Cancer
NCT00765765 · TERMINATED · slow accrual
“Slow accrual”
Agatolimod and Trastuzumab in Treating Patients With Locally Advanced or Metastatic Breast Cancer
NCT00824733 · TERMINATED · slow accrual
“Inaccurate patient accrual for trial”
Study of Panobinostat Monotherapy in Women With v-ERB-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 (HER2) Positive Locally Recurrent or Metastatic Breast Cancer
NCT00777335 · TERMINATED · slow accrual
“Very low recruitement rate.”
Relaxation and Visualization Therapy for Breast Cancer Patients
NCT00691119 · TERMINATED · slow accrual
“Inadequate recruitment”
S0716 Vandetanib and Docetaxel in Treating Patients With Advanced Solid Tumors
NCT00937417 · WITHDRAWN · other
“Withdrawn because SWOG no longer pursuing this study at this time”
Sorafenib and Fulvestrant in Treating Patients With Locally Advanced or Metastatic Breast Cancer That Did Not Respond to Aromatase Inhibitor Therapy
NCT00722072 · TERMINATED · funding business
“Sponsor pulled funding and low accrual”
Vaccine Therapy in Treating Women With Previously Treated Metastatic Breast Cancer
NCT00706615 · WITHDRAWN · slow accrual
“no accrual”
Histocompatibility Leukocyte Antigen (HLA)-A*0201 Restricted Peptide Vaccine Therapy in Patients With Breast Cancer
NCT00677326 · TERMINATED · slow accrual
“Difficulty in recruiting”
Trial of 2nd Generation Anti-CEA Designer T Cells in Metastatic Breast Cancer
NCT00673829 · SUSPENDED · funding business
“Funding”
A Study to Evaluate the Antitumor Activity and Safety of IPI-504 in Patients With Advanced Breast Cancer
NCT00627627 · WITHDRAWN · funding business
“Redirect focus of the indication”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.