Autopsy report · NCT07353229

68Ga-Dotatate PET and MRI Guided Radiation Dose Escalation for High Risk Meningioma

“dose escalation trial, and the first 3 patients (who made up a cohort) were all accrued”

The sponsor’s own words in the registry.

Life of this trial

• Registered 4 months after it had already started.
• Suspended: paused, and may or may not restart.
• 24 participants planned (an estimate, not an actual count).

Vital statistics

Status

Suspended

Phase

Phase 1

Sponsor

Thomas Jefferson University

Sponsor type

University, hospital or other

Conditions

High Risk Meningioma; Recurrent Meningioma

Interventions

⁶⁸Ga-Dotatate PET and MRI Guided Radiation Therapy; Magnetic Resonance Imaging (MRI); 68Ga-Dotatate PET Imaging; MD Anderson Symptom Inventory Bain Tumor form (MDASI-BT); EuroQol-5 Dimension (ED-5D)

Participants

24 (planned, not actual)

Sites

1

Countries

United States

Trials that died the same way

• Efficacy and Safety of SYNB1934 in Patients With PKU (SYNPHENY-3)
  “Based on a review of interim data from participants in the dose-escalation phase, it was determined that the study was unlikely to meet the primary endpoint.” (74% match in meaning)
• Study to Evaluate the Safety of AT2220 (Duvoglustat) in Pompe Disease
  “Per protocol, 3 sequential dose cohorts were planned. Study discontinued by Sponsor based upon serious adverse events in first 2 of 3 participants in Cohort 1.” (71% match in meaning)
• A Clinical Study to Evaluate the Safety, Tolerability, PK, PD, and Efficacy of KBP-089 in Patients With T2DM
  “The trial was planned to be conducted in 4 cohorts but was terminated after completion of Cohort 2 for strategic reasons due to limited PD effects.” (63% match in meaning)
• Stop Exogenous Allergic Alveolitis (EAA) in Childhood
  “After several years of recruitment only 4 patients were included. Study timelines for study completition too long. Decided to terminate trial.” (62% match in meaning)
• Effectiveness of Periocular Drug Injection in CATaract Surgery
  “Results of interim analysis: stop the trial due to one group being significantly different from the other three groups. Furthermore, shortage of study medication.” (62% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.