Autopsy report · NCT05158699

Effectiveness of Periocular Drug Injection in CATaract Surgery

“Results of interim analysis: stop the trial due to one group being significantly different from the other three groups. Furthermore, shortage of study medication.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 1 month after it had already started.
• Ran for about 2 years 10 months before it stopped.
• 628 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

Luigi Rondas

Sponsor type

University, hospital or other

Conditions

Macular Edema; Cystoid Macular Edema; Retinal Disease; Cataract; Lens Diseases; Eye Diseases

Interventions

Bromfenac; Dexamethasone; Triamcinolone Acetonide; Ketorolac-Phenylephrine Ophthalmic 0.3%-1% Intraocular Solution

Participants

628

Sites

10

Countries

Austria, Germany, Netherlands, Portugal

Trials that died the same way

• Impact of an Immune Modulator Dimethyl Fumarate on Acute Ischemic Stroke
  “The interim analysis of another associated study is not very effective” (74% match in meaning)
• LBH589 in Refractory Myelodysplastic Syndromes (MDS)
  “Per protocol, the results of a planned interim analysis demonstrated insufficient efficacy and led to early termination of the study.” (73% match in meaning)
• ACZ885 for the Treatment of Abdominal Aortic Aneurysm
  “The results of a third interim analysis (ad hoc) indicated a lack of efficacy and futility in continuing the trial.” (73% match in meaning)
• A Study to Assess the Anti-fatigability Effect of CK-2127107 in Elderly Male and Female Subjects With Limitations in Mobility
  “Lack of efficacy determined at interim analysis” (72% match in meaning)
• A Phase 2 Study of Intravitreal AVD-104 in Diabetic Macular Edema
  “The trial was stopped early due to insufficient study drug supply and study funding constraints” (72% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.