Autopsy report · NCT00688597

Study to Evaluate the Safety of AT2220 (Duvoglustat) in Pompe Disease

“Per protocol, 3 sequential dose cohorts were planned. Study discontinued by Sponsor based upon serious adverse events in first 2 of 3 participants in Cohort 1.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 6 months before it started.
• Ran for about 1 year before it stopped.
• 3 participants enrolled.
• Results were posted on the registry 8 years 8 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Amicus Therapeutics

Sponsor type

Industry

Conditions

Pompe Disease

Interventions

Duvoglustat

Participants

3

Sites

1

Countries

United States

Trials that died the same way

• Safety and Pharmacokinetics of Subcutaneous Dose of IMG-007 in Healthy Participants
  “Cohorts 1 and 2 were completed. Cohort 3 was cancelled because it was no longer necessary based on information from another study. No safety concerns were noted.” (71% match in meaning)
• Safety and Efficacy Evaluation of Bosutinib Plus Atezolizumab in Newly Diagnosed Chronic Leukemia Adult Patients
  “The study has been prematurely terminated due to the onset of 2 dose limiting toxicities in 2 patients.” (71% match in meaning)
• 68Ga-Dotatate PET and MRI Guided Radiation Dose Escalation for High Risk Meningioma
  “dose escalation trial, and the first 3 patients (who made up a cohort) were all accrued” (71% match in meaning)
• A Clinical Study to Evaluate the Safety, Tolerability, PK, PD, and Efficacy of KBP-089 in Patients With T2DM
  “The trial was planned to be conducted in 4 cohorts but was terminated after completion of Cohort 2 for strategic reasons due to limited PD effects.” (69% match in meaning)
• Evaluation of Revumenib in Participants With Colorectal Cancer and Other Solid Tumors
  “Study was terminated by sponsor after Phase 1b as pre-defined signals of efficacy were not met in the Phase 1b dose expansion cohort.” (67% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.