Autopsy report · NCT05889793

Evaluating Emetine for Viral Outbreaks (EVOLVE)

“The study was terminated due to insufficient participant enrollment resulting from a lower-than-expected number of COVID-19 cases”

The sponsor’s own words in the registry.

Life of this trial

• Registered 1 year before it started.
• Ran for about 1 year 7 months before it stopped.
• 4 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 2, Phase 3

Sponsor

Johns Hopkins University

Sponsor type

University, hospital or other

Conditions

COVID-19

Interventions

Emetine Hydrochloride; Placebo

Participants

4

Sites

2

Countries

Nepal, United States

Trials that died the same way

• Threshold Response of Lumbar Selective Nerve Root Block in Predicting Good Outcome Following Lumbar Foraminotomy
  “The study was terminated early due to a number of concurrent issues: low enrollment, limited data and COVID-19.” (86% match in meaning)
• A Study of Deflazacort (Emflaza®) in Participants With Limb-Girdle Muscular Dystrophy 2I (LGMD2I)
  “The study was terminated early due to low enrollment and missing efficacy assessment data due to missed visits related to COVID-19.” (85% match in meaning)
• fMRI-neuronavigated rTMS Treatment for Symptoms of Depression Associated With Concussive TBI in the Military Population
  “Study terminated due to COVID-19 restrictions” (85% match in meaning)
• Peripheral Nerve Stimulation for Back
  “Due to COVID-19 and other factors this study was terminated early and the patients currently enrolled are being used as a small pilot study.” (82% match in meaning)
• Changing Developmental Trajectories Through Early Treatment
  “Participant enrollment was hindered by the COVID-19 pandemic and the study was ultimately terminated.” (82% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.