COVID-19

Why trials studying COVID-19 stopped, in this sample of ClinicalTrials.gov.

67 stopped trials with a clear reason; 88% ended for non-scientific reasons.

Trials

• Efficacy and Safety of NVX-CoV2705
  NCT07086222 · TERMINATED · funding business
  “The study was terminated early due to low COVID-19 incidence and high population immunity, limiting meaningful vaccine efficacy assessment. The decision was made in consultation with FDA/CBER and was unrelated to safety concerns.”
• Study of Cysteamine-pantetheine Disulfide (TTI-0102) in Mild to Moderate COVID-19
  NCT05212662 · WITHDRAWN · logistics pi
  “Sponsor is not pursuing the COVID-19 indication at this time.”
• Evaluation of COVID-19 Vaccines Given as a Booster in Healthy Adults in Indonesia (MIACoV Indonesia)
  NCT05387317 · WITHDRAWN · funding business
  “Trial cancelled prior to commencement due to lack of funding.”
• Treatment of Long CoronaVirus Disease (COVID) (TLC) Feasibility Trial
  NCT05946551 · TERMINATED · funding business
  “Study was terminated due to lack of funding.”
• Implementation of the Integrated Care of Older People App and ICOPE Monitor in Primary Care (ICOPE)
  NCT04413877 · WITHDRAWN · funding business
  “Lack of funding to iniciate and conduct the registered study”
• Immunogenicity and Safety Study of SCB-2023 Vaccine as a Booster in Adults
  NCT05926440 · WITHDRAWN · other
  “we has selected a new candidate vaccine which is monovalent.”
• LACTYFERRIN™ Forte and ZINC Defense™ and Standard of Care (SOC) vs SOC in the Treatment of Non-hospitalized Patients With COVID-19
  NCT05783180 · WITHDRAWN · funding business
  “Sponsor decided not to move forward with the trial”
• Study on the Safety and Efficacy of Meplazumab for Injection Patients COVID-19
  NCT05679492 · WITHDRAWN · logistics pi
  “Based on current epidemic situation in China, there is few Mild and Moderate COVID-19 patients.”
• Inpatient COVID-19 Lollipop Study
  NCT05801341 · TERMINATED · manufacturing supply
  “Lab evaluation of lollipop samples no longer available.”
• Phase I-II Trial of Dendritic Cell Vaccine to Prevent COVID-19 in Adults
  NCT04386252 · WITHDRAWN · other
  “The FDA put our protocol on clinical hold and never gave an okay to start, so we decided not to proceed”
• CORONA: A Study Using DeltaRex-G Gene Therapy for Symptomatic COVID-19
  NCT04378244 · WITHDRAWN · funding business
  “Lack of Funding”
• Neutralizing Power of Anti-SARS-CoV-2 (Anti-COVID-19) Serum Antibodies
  NCT05315583 · TERMINATED · slow accrual
  “Now that the COVID period has passed, patient recruitment has fallen off.”
• Safety and Immunogenicity of Inactivated Heterologous Booster Vaccination
  NCT05545683 · WITHDRAWN · funding business
  “funding was suspended”
• Trial of 2nd Booster Dose of COVID-19 Vaccine
  NCT05539703 · WITHDRAWN · regulatory
  “Did not get the necessary approvals in time.”
• Phonation Therapy to Improve Symptoms and Lung Physiology in Patients Referred for Pulmonary Rehabilitation
  NCT05621967 · WITHDRAWN · logistics pi
  “Change in location of Pulmonary Rehab at our institution”
• The KIN-FAST Trial (KIN001 For Accelerated Symptoms Termination) in Non Hospitalized Patients Infected With SARS-CoV-2
  NCT05659459 · TERMINATED · funding business
  “Sponsor went bankrupt - trial was discontinued due to lack of financing”
• Plerixafor in Acute Respiratory Distress Syndrome Related to COVID-19 (Phase IIb)
  NCT05411575 · WITHDRAWN · slow accrual
  “No participants Enrolled”
• Hexoskin Feasibility Study With COVID-19 Patients
  NCT04453891 · WITHDRAWN · logistics pi
  “Internal timeline was delayed, logistics delays”
• Observation of the Immune Response After COVID-19 Additional Vaccine Doses in Chronic Patients in Hemodialysis Therapy
  NCT05142501 · TERMINATED · slow accrual
  “Low recruitment”
• Mechanisms Underlying Cardiovascular Consequences Associated With COVID-19 and Long COVID
  NCT06427512 · WITHDRAWN · funding business
  “Funding not available”
• Controlled Trial of Angiotensin Receptor Blocker (ARB) & Chemokine Receptor Type 2 (CCR2) Antagonist for the Treatment of COVID-19
  NCT05122182 · TERMINATED · funding business
  “Withdrawal of funding support from the trial funder.”
• Leidos-Enabled Adaptive Protocol (LEAP-CT) for Evaluation of Post-exposure Prophylaxis for Newly-infected COVID-19 Patients
  NCT05077969 · TERMINATED · slow accrual
  “Low recruitment”
• The Utility of Camostat Mesylate in Patients With COVID-19 Associated Coagulopathy (CAC) and Cardiovascular Complications
  NCT04435015 · WITHDRAWN · funding business
  “No funding”
• A Phase 3 Randomized, Double-Blind Placebo Controlled, Multi-regional Trial to Evaluate the Efficacy and Safety of GT0918 for the Treatment of Mild to Moderate COVID-19 Male Patients
  NCT04869228 · TERMINATED · logistics pi
  “This decision is made on changing the development strategy of GT0918 to adapt ever-changing COVID-19 pandemic management globally.”
• Evaluation of ADG20 for the Prevention of COVID-19
  NCT04859517 · TERMINATED · safety
  “All primary efficacy data has been collected and analyzed. Based on the safety data gathered to date, it has been determined that continued participation by study subjects would not yield any additional beneficial safety information.”
• Clinical Trial to Evaluate the Safety and Efficacy of ATR-002 in Adult Hospitalized Patients With COVID-19
  NCT04776044 · TERMINATED · logistics pi
  “general circumstances around COVID-19 and current availability of hospitalized patients”
• NOWDx Test for the Detection of Antibodies to COVID-19 in Lay Persons
  NCT04799392 · TERMINATED · regulatory
  “FDA will not authorize COVID-19 Ab tests for use over-the-counter.”
• Trial to Promote Recovery From COVID-19 With Endocrine Therapy
  NCT04374279 · WITHDRAWN · logistics pi
  “Limited resources.”
• Study to Evaluate the Efficacy and Safety of Remdesivir in Participants With Severely Reduced Kidney Function Who Are Hospitalized for Coronavirus Disease 2019 (COVID-19)
  NCT04745351 · TERMINATED · funding business
  “The study was terminated due to study enrollment feasibility. This decision is not based on efficacy or safety concerns.”
• Study of mRNA Vaccine Formulation Against COVID-19 in Healthy Adults 18 Years of Age and Older
  NCT04798027 · TERMINATED · funding business
  “Sponsor's decision not to pursue further development of this product given the wide availability of authorized/approved mRNA COVID-19 vaccines”
• Safety and Immunogenicity of COVID-eVax, a Candidate Plasmid DNA Vaccine for COVID-19, in Healthy Adult Volunteers
  NCT04788459 · TERMINATED · logistics pi
  “The good progress of the Italian national vaccination campaign against COVID-19 made impossible to complete the study as planned.”
• Lymphatic Osteopathic Manipulative Medicine to Enhance Coronavirus (COVID-19) Vaccination Efficacy
  NCT05069636 · WITHDRAWN · logistics pi
  “The Principal Investigator left Rowan University School of Osteopathic Medicine.”
• Ocular Findings and Viral Persistence in Ocular Fluids in COVID-19 Survivors
  NCT04665752 · TERMINATED · slow accrual
  “Slow/Insufficient accrual”
• Study to Evaluate the Safety and Efficacy of Liquid Alpha1-Proteinase Inhibitor (Human) in Hospitalized Participants With Coronavirus Disease (COVID-19)
  NCT04547140 · TERMINATED · futility
  “Study Stopped for Futility”
• BinaxNOW for Evaluating Children for Infection With SARS-CoV-2 (COVID-19)
  NCT05087524 · TERMINATED · logistics pi
  “changes in in-person schooling per COVID-19 pandemic”
• InterLeukin-7 to Improve Clinical Outcomes in Lymphopenic Patients With COVID-19 Infection ( ILIAD-7-US-O )
  NCT04426201 · TERMINATED · slow accrual
  “POOR ACCRUAL”
• Ultramicronized Palmitoylethanolamide (PEA) Treatment in Hospitalized Participants With COVID-19
  NCT04619706 · TERMINATED · slow accrual
  “Difficulties recruiting new subjects”
• A Trial of NT-I7 in COVID-19 (SPESELPIS)
  NCT04501796 · TERMINATED · slow accrual
  “Study was halted due to lack of patient population resulting in slow enrollment.”
• An Outpatient Study Investigating Non-prescription Treatments for COVID-19
  NCT04621149 · TERMINATED · logistics pi
  “Unable to recruit participants due to decline in COVID-19.”
• Convalescent Plasma as Treatment for Subjects With Early COVID-19 Infection
  NCT04456413 · TERMINATED · slow accrual
  “Lack of accrual”
• Impact of Intravenous Lidocaine on Clinical Outcomes of Patients With ARDS During COVID-19 Pandemia
  NCT04609865 · TERMINATED · logistics pi
  “departure of the principal investigator and inclusion difficulties”
• Study to Evaluate the Efficacy and Safety of Remdesivir (GS-5734™) Treatment of Coronavirus Disease 2019 (COVID-19) in an Outpatient Setting
  NCT04501952 · TERMINATED · funding business
  “The study was terminated due to study enrollment feasibility and changing needs of non-hospitalized participants. This decision is not based on efficacy or safety concerns.”
• Keto-diet for Intubated Critical Care COVID-19
  NCT04358835 · WITHDRAWN · slow accrual
  “Study did not begin enrollment, multiple competing studies at same institution”
• PROphylaxis for paTiEnts at Risk of COVID-19 infecTion
  NCT04389359 · WITHDRAWN · regulatory
  “Regulatory approvals not received”
• Early Versus Late ECMO Therapy in COVID-19 Induced ARDS (ECMO-VID)
  NCT04341285 · WITHDRAWN · logistics pi
  “study protocol was changed to include non-COVID patients and registered under a different ID”
• Nudges to Improve Health Behaviors That Limit COVID-19 Spread
  NCT04379375 · TERMINATED · slow accrual
  “Slow enrollment rate”
• Efficacy Assessment of Methylprednisolone and Heparin in Patients With COVID-19 Pneumonia
  NCT04485429 · WITHDRAWN · logistics pi
  “It was not possible to perform the study due to the availability and logistics of porcine heparin”
• ANTIBODY-LEVEL BASED ANALYSIS OF COVID-19 CONVALESCENT SERUM (ABACCuS)
  NCT04432272 · TERMINATED · regulatory
  “The EUA for CCP was updated by FDA, stipulating that only high titer units be used. This study required untitered units. The study became infeasible”
• Ultrasonography in Norwegian Emergency Department Patients With Suspected Covid-19 Infection
  NCT04422691 · TERMINATED · logistics pi
  “lack of Covid-19 patients”
• ABX464 in Treating Inflammation and Preventing Acute Respiratory Failure in Patients With COVID-19
  NCT04393038 · TERMINATED · futility
  “Interim analysis concludes that the study is futile”
• Study of the Efficacy and Safety of a Single Administration of Olokizumab vs. Placebo in Addition to Standard Treatment in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection (COVID-19).
  NCT04452474 · WITHDRAWN · funding business
  “Sponsor's decision”
• Enoxaparin for Primary Thromboprophylaxis in Ambulatory Patients With COVID-19
  NCT04400799 · TERMINATED · other
  “due to results from interim analysis”
• Trial of Tocilizumab for Treatment of Severe COVID-19: ARCHITECTS
  NCT04412772 · TERMINATED · regulatory
  “Per Queen's Regulatory Office, study is terminated or expired.”
• The Role of Resistant Starch in COVID-19 Infection
  NCT04342689 · TERMINATED · slow accrual
  “Study was terminated due to low enrollment.”
• Azithromycin for COVID-19 Treatment in Outpatients Nationwide
  NCT04332107 · TERMINATED · futility
  “Futility”
• Azithromycin Added to Hydrochloroquine in Patients Admitted to Intensive Care With COVID-19: Randomised Controlled Trial
  NCT04339816 · TERMINATED · other
  “Steering Committee decision in accordance with stopping rule 1: Emergence of new data”
• Subcutaneous Sarilumab vs Placebo in Hospitalized Patients With Respiratory Distress Caused by COVID 19
  NCT07196306 · WITHDRAWN · slow accrual
  “no participants enrolled”
• In-vitro Diagnostic Test to Predict COVID-19 Mortality and Disease Severity
  NCT04368897 · WITHDRAWN · slow accrual
  “Not able to recruit subjects”
• VA Remote and Equitable Access to COVID-19 Healthcare Delivery (VA-REACH TRIAL)
  NCT04363203 · SUSPENDED · funding business
  “concerns related to study drug”
• Coronavirus (COVID-19) ACEi/ARB Investigation
  NCT04330300 · SUSPENDED · logistics pi
  “Challenges with funding and very low incidence of COVID-19 at Irish study site”
• Repurposing of Chlorpromazine in Covid-19 Treatment
  NCT04366739 · WITHDRAWN · regulatory
  “No favourable opinion obtained from the Ethics Committee”
• Corticosteroids During Covid-19 Viral Pneumonia Related to SARS-Cov-2 Infection
  NCT04344288 · TERMINATED · regulatory
  “Competent Authority's decision”
• Home Care for Patients With COVID-19: Active Monitoring in Two Italian Health Units (Casale Monferrato and Torino)
  NCT04361916 · TERMINATED · slow accrual
  “interrupted early due to the drastic reduction in the number of cases”
• Colchicine in COVID-19: a Pilot Study
  NCT04375202 · TERMINATED · slow accrual
  “Insufficient rate of patient accrual and newly available scientific evidence”
• COVID Cohort Study
  NCT04393155 · TERMINATED · funding business
  “Grant application to fund this work was not funded. We won't be posting data for this study.”
• Hydroxychloroquine Treatment of Healthcare Workers With COVID19 Illness at Montefiore
  NCT04350450 · WITHDRAWN · logistics pi
  “PI withdrew the submission to the IRB”
• Recombinant Human Angiotensin-converting Enzyme 2 (rhACE2) as a Treatment for Patients With COVID-19
  NCT04287686 · WITHDRAWN · regulatory
  “Without CDE Approval”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.