Autopsy report · NCT05784129

A Study of Guselkumab for the Treatment of Participants With Crohn's Disease After Surgical Resection

“Janssen made an internal business decision to discontinue the PROGRESS study. This decision is not related to any efficacy or safety concerns.”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 8 months before it stopped.
• 4 participants enrolled.
• Results were posted on the registry 1 year 1 month after it ended.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

Janssen Research & Development, LLC

Sponsor type

Industry

Conditions

Crohn's Disease

Interventions

Guselkumab; Placebo

Participants

4

Sites

11

Countries

Poland, United States

Trials that died the same way

• Effects of JNJ-53718678 in Adult and Adolescent Participants Who Had a Hematopoietic Stem Cell Transplantation and Who Are Infected With Respiratory Syncytial Virus (RSV)
  “A strategic decision was made to discontinue the study. The decision was not based on a safety concern.” (68% match in meaning)
• Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 562 in Subjects With r/r Diffuse Large B-cell Lymphoma, Mantle Cell Lymphoma, or Follicular Lymphoma
  “Amgen decided to discontinue study because of a business decision and not because of safety reasons” (67% match in meaning)
• Contribution of Hepatic and Intestinal Lipoproteins to Human Atherosclerosis
  “Study was never initiated and internal decision to discontinue initiation process” (64% match in meaning)
• A Trial to Evaluate the Efficacy and Safety of PQ912 in Patients With Early AD
  “It has been made the strategic decision to terminate the study. This decision to terminate the study early is not being made for safety reasons.” (62% match in meaning)
• TT-816 As Monotherapy or in Combination with a PD-1 Inhibitor in Patients with Advanced Cancers (SEABEAM) (MK3475-E88)
  “Company operational decision. Decision to stop study is not due to safety or efficacy concerns.” (62% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.