Crohn's Disease

Why trials studying Crohn's Disease stopped, in this sample of ClinicalTrials.gov.

25 stopped trials with a clear reason; 88% ended for non-scientific reasons.

Trials

• A Study of Guselkumab for the Treatment of Participants With Crohn's Disease After Surgical Resection
  NCT05784129 · TERMINATED · funding business
  “Janssen made an internal business decision to discontinue the PROGRESS study. This decision is not related to any efficacy or safety concerns.”
• Reduce Crohn's-Associated Diarrhea With Sodium Channel Therapy
  NCT04456517 · TERMINATED · slow accrual
  “Low accrual and subject engagement”
• Exclusive Enteral Nutrition vs. Infliximab in Chinese CD Patients
  NCT04530877 · WITHDRAWN · funding business
  “no funding”
• A Study Evaluating the Efficacy and Safety of Oral Etrasimod in the Treatment of Adult Participants With Moderately to Severely Active Crohn's Disease
  NCT04173273 · TERMINATED · futility
  “The study was prematurely discontinued due to a lack of efficacy in sub-study 1”
• Filgotinib in Long-Term Extension Study of Adults With Crohn's Disease
  NCT02914600 · TERMINATED · funding business
  “development program for filgotinib for participants with Crohn's disease has been stopped”
• MOlecular BIomarkers and Adherent and Invasive Escherichia Coli (AIEC) Detection Study In Crohn's Disease Patients
  NCT02882841 · TERMINATED · slow accrual
  “Poor accrual”
• High-dose Cyclophosphamide for Severe Refractory Crohn Disease
  NCT01836289 · WITHDRAWN · slow accrual
  “Too difficult to recruit given new Crohn's medications approved”
• One Year Study of Rifaximin Delayed Release (DR) Tablets in Crohn's Disease
  NCT02240121 · TERMINATED · slow accrual
  “The study was terminated early due to difficulty in enrollment and lack of clinical study drug access.”
• Autologous Hematopoietic Stem Cell Transplantation for Crohn's Disease Treatment
  NCT01932658 · WITHDRAWN · funding business
  “patients insurance would not cover the cost of the study procedures”
• A Crohn's Disease Diet to Reduce Symptoms of Crohn's Disease
  NCT01897090 · WITHDRAWN · slow accrual
  “Unable to recruit”
• Assessment of Mucosal Activity to Improve the Prognosis of Patients With Crohn's Disease Treated With Immunosuppressants
  NCT01562951 · TERMINATED · slow accrual
  “Not enough patient population according to selection criteria to complete the study”
• A Phase II Study to Assess the Efficacy and Safety of Olokizumab in Patients With Crohn's Disease
  NCT01635621 · WITHDRAWN · funding business
  “Study was withdrawn due to delay in timelines. There were no safety concerns regarding the study or the compound in the decision to withdraw the trial.”
• Investigation of Sexual Function in Crohn's Disease Patients With Perianal Fistulas
  NCT01635543 · WITHDRAWN · slow accrual
  “This study was terminated due to some challenges in recruitment process”
• Open Label Extension Study to Protocol C2/13/DR-6MP-02
  NCT01433432 · WITHDRAWN · funding business
  “Sponsor withdrew support for study due to reorganization and project prioritization”
• Open-Label Extension Study of GSK1605786A
  NCT01318993 · TERMINATED · futility
  “This study was terminated due to the lack of efficacy of GSK1605786A in Crohn's disease based on the results of Study CCX114151.”
• Long-term Safety Study of Brodalumab in Adults With Crohn's Disease
  NCT01199302 · TERMINATED · safety
  “The study was terminated early based on an imbalance in worsening Crohn's disease in active treatment groups.”
• Decisional Influences and Inflammatory Bowel Disease (IBD) Patients' Medication Use
  NCT00968721 · TERMINATED · funding business
  “lack of support”
• Vitamin D Supplementation as Non-toxic Immunomodulation in Children With Crohn's Disease
  NCT01046773 · TERMINATED · slow accrual
  “Low enrollment”
• NIH Substudy of AIN457 (Anti-IL-17 Monoclonal Antibody) for Treatment of Moderate to Severe Crohn's Disease
  NCT00936585 · TERMINATED · funding business
  “Study halted by the sponsor”
• The Effect on Mucosal Healing With Pentasa Sachet in Mild to Moderate Active "Drug: Crohn's Disease"
  NCT00245505 · TERMINATED · slow accrual
  “Study terminated due to lack of eligible patients”
• Adjuvant Vitamin D With Corticosteroids in Active Crohn's Disease
  NCT00672763 · WITHDRAWN · slow accrual
  “Unable to recruit adequate trial participants”
• Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis
  NCT00513552 · WITHDRAWN · slow accrual
  “No patient”
• A Study of Abatacept in Patients With Active Crohn's Disease
  NCT00406653 · TERMINATED · funding business
  “Sponsor Decision”
• Study of Antibiotics in the Treatment of Colonic Crohn's Disease
  NCT00257699 · TERMINATED · slow accrual
  “Inadequate recruitment to meet completion date”
• Remicade® Crohn's Disease Registry Across Canada (Study P02793)
  NCT00755937 · TERMINATED · regulatory
  “Satisfied a post-marketing commitment to Canadian Health Authorities.”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.