Autopsy report · NCT03919162

A Trial to Evaluate the Efficacy and Safety of PQ912 in Patients With Early AD

“It has been made the strategic decision to terminate the study. This decision to terminate the study early is not being made for safety reasons.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 2 years 7 months before it started.
• Ran for about 2 years 9 months before it stopped.
• 112 participants enrolled.
• Results were posted on the registry 1 year 4 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Vivoryon Therapeutics N.V.

Sponsor type

Industry

Conditions

Alzheimer Disease

Interventions

PQ912; Placebo

Participants

112

Sites

22

Countries

United States

Trials that died the same way

• A Study of TCD601 (Siplizumab) in New Onset Type 1 Diabetes Patients
  “The study has been early terminated due to business reasons. This decision is not related to any safety, efficacy, or regulatory concerns.” (84% match in meaning)
• Effects of JNJ-53718678 in Adult and Adolescent Participants Who Had a Hematopoietic Stem Cell Transplantation and Who Are Infected With Respiratory Syncytial Virus (RSV)
  “A strategic decision was made to discontinue the study. The decision was not based on a safety concern.” (82% match in meaning)
• An Evaluation Of PF-03715455 In Moderate To Severe Uncontrolled Asthma
  “The termination was due to business reasons. No safety or efficacy concerns contributed to the termination of the study” (80% match in meaning)
• Pre-operative Mocetinostat (MGCD0103) and Durvalumab (MEDI4736) (PRIMED) for Squamous Cell Carcinoma of the Oral Cavity
  “The study has been terminated due to a change in internal prioritization and not due to any safety concerns.” (80% match in meaning)
• Surgical Treatment of Chronic Neuropathic Pain
  “The study was terminated due to lower than expected enrollment. The decision to terminate the study was not based on any safety or efficacy concerns.” (79% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.