Autopsy report · NCT05492500

A Study of Ponsegromab in People With Heart Failure

“Following a prespecified interim analysis, and in consultation with the independent Data Monitoring Committee, the Sponsor terminated the study”

The sponsor’s own words in the registry.

Life of this trial

• Registered 2 months before it started.
• Ran for about 2 years 5 months before it stopped.
• 455 participants enrolled.
• Results were posted on the registry 1 year after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Pfizer

Sponsor type

Industry

Conditions

Heart Failure

Interventions

Main cohort (Cohort A): Ponsegromab low dose; Main cohort (Cohort A): Ponsegromab medium dose; Main cohort (Cohort A): ponsegromab high dose; Main cohort (Cohort A): Matched placebo; Open-label, PK Cohort (Cohort B): ponsegromab low dose; Open-label, PK Cohort (Cohort B): ponsegromab medium dose

Participants

455

Sites

122

Countries

Australia, Canada, China, Czechia, Germany, Hungary, Japan, Poland, Spain, United Kingdom, United States

Trials that died the same way

• Effect of Enzymes on Dental Biofilm Accumulation in Healthy Individuals
  “The study was terminated after interim data analysis” (85% match in meaning)
• Safety Study of the VEGA UV-A System to Treat Keratoconus
  “The sponsor terminated the study prior to data analysis for financial reasons.” (83% match in meaning)
• GSK1572932A Antigen-Specific Cancer Immunotherapeutic as Adjuvant Therapy in Patients With Non-Small Cell Lung Cancer
  “The study was terminated following assessment of the lack of efficacy of the study product by the Independent Data monitoring Committee for the study.” (78% match in meaning)
• Long-term, Non-interventional, Observational Study Following Treatment With Fate Therapeutics FT500 Cellular Immunotherapy
  “This study was terminated by the Sponsor.” (76% match in meaning)
• Study Evaluating PPM-204 In Subjects With Type 2 Diabetes
  “Study terminated as a result of interim analysis not meeting predetermined criteria.” (76% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.