Pfizer

Why trials sponsored by Pfizer stopped, in this sample of ClinicalTrials.gov.

55 stopped trials with a clear reason; 78% ended for non-scientific reasons.

Trials

• A Study to Learn About the Study Medicine Called PF-07258669 in Older Adults Including Those at Risk of Malnutrition
  NCT07086664 · TERMINATED · funding business
  “The study was prematurely discontinued due to a business decision. The decision to terminate the study is not related to a safety concern.”
• A Study to Learn How Different Tablets of the Study Medicine Mevrometostat Are Taken up Into the Blood in Healthy Adults
  NCT06661694 · WITHDRAWN · funding business
  “sponsor decision”
• Study to Learn About How the Study Medicines Called PF-07976016 and PF-06882961 Are Taken Up by the Body, and if Either of Them Change How the Body Processes the Other Medicine in Otherwise Healthy Adults With Overweight or Obesity
  NCT06910839 · TERMINATED · funding business
  “The sponsor has made the decision to discontinue development of danuglipron (PF-06882961). As such, this study was discontinued prior to PF-06882961 administration.”
• A Study to Learn About the Study Medicine PF-07985045 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Change in a Gene.
  NCT06704724 · TERMINATED · funding business
  “The trial was terminated for strategic business reasons; the decision was not based on any safety and/or efficacy concerns.”
• Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Recifercept in Healthy Chinese Participants
  NCT05061277 · WITHDRAWN · funding business
  “Pfizer has decided to cancel study C4181006 due to strategic considerations. This decision is not due to any specific reasons or requests from any regulatory authorities. No participants have been enrolled in this study.”
• A Drug-Drug Interaction Study to Estimate the Effect of PF-07081532 on the Pharmacokinetics of Dabigatran and Rosuvastatin in Overweight or Obese Adult Participants
  NCT05788328 · TERMINATED · funding business
  “The decision to terminate clinical development of lotiglipron is based on pharmacokinetic data from Phase 1 drug-drug-interaction studies and laboratory measurements of elevated transaminases in these Phase 1 studies as well as a Phase 2 study.”
• A Study to Learn About the Effect of Avelumab First-Line Maintenance in Canadian People With Advanced Bladder Cancer
  NCT05699135 · TERMINATED · funding business
  “The trial was terminated for strategic reasons. The decision was not based on any safety and/or efficacy concerns.”
• A Study to Learn About a Modified RNA Vaccine Against Shingles in Healthy Adults
  NCT05703607 · TERMINATED · funding business
  “Strategic decision made by the company”
• A Study to Evaluate the Effect of the Experimental GLP-1 Drug PF-07081532 on Blood Levels of Common Birth Control Pills, and Drugs Omeprazole and Midazolam, and Effect of GLP-1 Drug Semaglutide on Midazolam Blood Levels in Healthy Adults With Weight in the Obesity Range
  NCT05671653 · TERMINATED · funding business
  “The decision to terminate clinical development of lotiglipron is based on pharmacokinetic data from Phase 1 drug-drug-interaction studies and laboratory measurements of elevated transaminases in these Phase 1 studies as well as a Phase 2 study.”
• GBT021601-022: A Study of GBT021601 in Participants With Sickle Cell Disease (SCD)
  NCT05632354 · TERMINATED · other
  “Study terminated as data obtained from this non-placebo-controlled trial may not be informative for the interpretation of the benefits and risks of osivelotor”
• Safety and Efficacy Active Drug vs. Placebo in Subjects With Asthma
  NCT04987944 · TERMINATED · funding business
  “Strategic decision to discontinue the study based on adjusted clinical development plan. This decision is not based on any safety concerns.”
• A Study Evaluating the Safety, Tolerability, and Effect on Microvascular Obstruction of Intravenous Temanogrel in Adult Participants Undergoing Percutaneous Coronary Intervention
  NCT04848220 · TERMINATED · funding business
  “Business decision”
• Efficacy, Safety, and Tolerability of ATM-AVI in the Treatment of Serious Infection Due to MBL-producing Gram-negative Bacteria
  NCT03580044 · TERMINATED · slow accrual
  “Recruitment of patients with serious infections caused by gram-negative bacteria producing MBL has been challenging. Date study terminated: 16-Dec-2022.”
• Study to Test the Safety and Tolerability of PF-07209960 in Advanced or Metastatic Solid Tumors
  NCT04628780 · TERMINATED · funding business
  “Pfizer has made an internal business decision to not continue further development of PF-07209960. This decision was not based on safety or regulatory considerations”
• Study to Evaluate the Effect of GBT440 on TCD in Pediatrics With Sickle Cell Disease
  NCT04218084 · TERMINATED · regulatory
  “Emerging clinical data evaluated by Pfizer and shared with regulatory authorities indicates that the risk profile of voxelotor in people with SCD exceeds the benefits observed in previously generated global research and requires further assessment.”
• A BRIDGING STUDY OF PF-06439535 (CN) PLUS PACLITAXEL-CARBOPLATIN VERSUS BEVACIZUMAB PLUS PACLITAXEL-CARBOPLATIN IN NSCLC
  NCT04325698 · TERMINATED · funding business
  “The study was terminated as part of the decision by Pfizer to halt its biosimilars programs in China.”
• NOAC Portuguese Real World Study
  NCT04808934 · WITHDRAWN · funding business
  “Withdrawn due to COVID19 pandemic. Several delays affected this study, therefore company decided to not conduct the study. It was cancelled prior to any enrollment.”
• A Study of Duloxetine Hydrochloride Hard Gelatinous Capsule Compared To Cymbalta
  NCT03729284 · WITHDRAWN · funding business
  “This study has been cancelled prior to FSFV due to business reasons”
• Evaluation of Pharmacokinetics, Safety, and Tolerability of Ceftazidime-avibactam in Neonates and Infants.
  NCT04126031 · TERMINATED · funding business
  “Following regulatory consultation, the Sponsor has decided to terminate the study and analyze the current dataset. The decision to terminate was solely based on a business decision, not due to safety concerns.”
• Dose Escalation Study to Evaluate the Safety, Tolerability, PK and PD of Voxelotor in Patients With SCD
  NCT04247594 · TERMINATED · funding business
  “Data will not inform further development of Voxelotor”
• A Study Evaluating the Efficacy and Safety of Oral Etrasimod in the Treatment of Adult Participants With Moderately to Severely Active Crohn's Disease
  NCT04173273 · TERMINATED · futility
  “The study was prematurely discontinued due to a lack of efficacy in sub-study 1”
• Avelumab With Bempegaldesleukin With or Without Talazoparib or Enzalutamide in Advanced or Metastatic Solid Tumors
  NCT04052204 · TERMINATED · other
  “Study prematurely terminated as the experimental treatments evaluated in study B9991040 may not provide additional clinical benefit over current or future Standard of Care in the different therapeutic indications that this trial was to evaluate.”
• Study to Test the Safety and Tolerability of PF-07062119 in Patients With Selected Advanced or Metastatic Gastrointestinal Tumors.
  NCT04171141 · TERMINATED · funding business
  “Study was terminated due to strategic considerations and not due to safety.”
• A Renal Impairment Study for PF-06651600
  NCT04037865 · TERMINATED · logistics pi
  “The study was terminated due to extensive Covid-19 delay.”
• PF-06952229 Treatment in Adult Patients With Advanced Solid Tumors
  NCT03685591 · TERMINATED · funding business
  “The decision to stop enrollment was due to strategic considerations and not due to any specific safety reasons or request from a regulatory authority.”
• Talazoparib For Neoadjuvant Treatment Of Germline BRCA1/2 Mutation Patients With Early Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer
  NCT03499353 · TERMINATED · funding business
  “This study was terminated based on Pfizer's change in clinical development strategy not related to safety and efficacy.”
• A Study of PF-06873600 in People With Cancer
  NCT03519178 · TERMINATED · funding business
  “Per business decision, but not due to safety concerns or regulatory request.”
• A Study of Tofacitinib in Patients With Ulcerative Colitis in Stable Remission
  NCT03281304 · TERMINATED · funding business
  “The study terminated early due to business reasons, with the study already meeting its primary objective. The decision to terminate the trial was not based on any safety and/or efficacy concerns.”
• PF-06804103 Dose Escalation in HER2 Positive and Negative (Negative Only in Part 2) Solid Tumors
  NCT03284723 · TERMINATED · funding business
  “The trial was terminated based on the stage in drug development and assessment of PF-06804103 relative to the leading external competition. The decision was not due to a safety concern.”
• Understanding Hemophilia A and B Drug Dosage Administration Patterns
  NCT03248141 · TERMINATED · slow accrual
  “Study recruitment was stopped due to difficulty in enrolling the targeted number of patients on March 21, 2018. See details in Description section.”
• Long-term Safety and Efficacy Study and Dose-Escalation Substudy of PF 06838435 in Individuals With Hemophilia B
  NCT03307980 · TERMINATED · funding business
  “The study was terminated early due to Sponsor and participants may transition into a long-term follow-up study. The decision to terminate the trial was not based on any safety and/or efficacy concerns.”
• Study To Compare Avelumab In Combination With Standard of Care Chemoradiotherapy (SoC CRT) Versus SoC CRT for Definitive Treatment In Patients With Locally Advanced Squamous Cell Carcinoma Of The Head And Neck (JAVELIN HEAD AND NECK 100)
  NCT02952586 · TERMINATED · futility
  “The trial prematurely terminated as recommended by the E-DMC because the boundary for futility has been crossed.”
• Ph1b/2 Study of PF-04136309 in Combination With Gem/Nab-P in First-line Metastatic Pancreatic Patients
  NCT02732938 · TERMINATED · funding business
  “Pfizer made a business-related decision on 04May2017 to terminate study based on change in portfolio prioritization, and is not due to safety or efficacy.”
• Pharmacokinetic and Pharmacodynamic Study of Bococizumab Alone and When Combined With Recombinant Human Hyaluronidase
  NCT02667223 · TERMINATED · funding business
  “The study was terminated early on July 8, 2016 due to business priorities regarding study execution.”
• Safety, Tolerability and Efficacy of Ceftaroline in Paediatrics With Late-Onset Sepsis
  NCT02424734 · TERMINATED · slow accrual
  “Study was terminated on 22Dec2017 due to slow enrollment; there were no safety or efficacy concerns.”
• An Evaluation Of PF-03715455 In Moderate To Severe Chronic Obstructive Pulmonary Disease
  NCT02366637 · TERMINATED · funding business
  “Study terminated on 7 April 2015 for business reasons. No safety and/or efficacy concerns contributed to the termination of the study”
• A Study In Healthy Elderly People To Evaluate Safety, Toleration, Pharmacokinetics and Pharmacodynamics of Multiple Oral Doses Of PF-06743649
  NCT02170012 · TERMINATED · safety
  “The study was prematurely terminated on 17th December 2014 due to safety concerns.”
• Evaluation of Ceftaroline Fosamil vs Vancomycin Plus Aztreonam in the Treatment of Patients With Skin Infections.
  NCT02202135 · TERMINATED · slow accrual
  “Overall study status is changed to "Terminated" due to low enrollment”
• LGX818 for Patients With BRAFV600 Mutated Tumors
  NCT01981187 · TERMINATED · slow accrual
  “Due to slow enrollment and lack of response observed during the enrollment period, the Sponsor decided to close study enrollment early on 28 January 2015”
• Multiple Dose Study Of PF-05231023 In Obese Adult Subjects
  NCT01923389 · TERMINATED · funding business
  “The study was terminated on December 19th, 2013 due to a business decision by the Sponsor. No safety concerns have been observed in this study.”
• A Pilot Bioavailability Study of 3 Test Tablet Formulations of Bazedoxifene Compared With A Reference Tablet Formulation of Bazedoxifene/Conjugated Estrogens in Healthy Postmenopausal Women
  NCT01634789 · TERMINATED · slow accrual
  “This study was terminated on 10 December 2012 due to low enrollment. The decision to terminate the study was not based on safety or efficacy issues.”
• Long-Term Open-Label, Safety Study Of Sitaxentan Sodium In Japanese Pulmonary Arterial Hypertension Patients
  NCT01210443 · TERMINATED · safety
  “Safety Issue: The trial was prematurely terminated on Dec 9, 2010, due to safety concerns, specifically new emerging evidence of hepatic injury.”
• A Pharmacokinetic Drug-Drug Interaction (DDI) Study Between Sitaxsentan And Sildenafil, And Between Sitaxsentan And Tadalafil After Multiple Doses
  NCT01244620 · TERMINATED · safety
  “Safety Issue: The trial was prematurely terminated on Dec 9, 2010, due to safety concerns, specifically new emerging evidence of hepatic injury.”
• Post Marketing Surveillance On The Safety And Tolerability Of Sunitinib Malate (Sutent) For Filipino Patients
  NCT01073644 · TERMINATED · slow accrual
  “The study was prematurely discontinued due to poor recruitment on 18th April 2013. There were no safety concerns that led to the decision to terminate.”
• A Study Of Kappa Opioid Receptor Occupancy Of PF-04455242, Using PET (Positron Emission Tomography)
  NCT00939887 · TERMINATED · safety
  “This study was terminated on January 6, 2010, due to toxicology findings in animals exposed to PF-04455242 for three months.”
• A Study To Evaluate The Safety Of Voriconazole As Treatment Of Invasive Aspergillosis (Fungal Infection) And Other Rare Molds In Children
  NCT00836875 · TERMINATED · slow accrual
  “This protocol terminated prematurely on July 8, 2013 due to slow enrollment, not because of any safety issues or concerns.”
• Multiple Dose Study To Investigate The Effects Of Fesoterodine And Solifenacin On Gastrointestinal Transit
  NCT00832650 · TERMINATED · futility
  “Protocol A0221057 was terminated on December 25, 2009 for futility. There were no safety concerns related to this decision.”
• A Clinical Study To Investigate The Effectiveness And Safety Of Tanezumab In Treating Pain Associated With Endometriosis
  NCT00784693 · TERMINATED · slow accrual
  “Further recruitment into the study was ceased on 10th December 2009, not attributed to safety. All patients recruited in the study completed all study visits.”
• Study to Evaluate Eye Function in Patients Taking Linezolid for Six Weeks or Greater
  NCT00359632 · TERMINATED · slow accrual
  “Study was stopped due to poor enrollment on 28 Feb 2012. Reason for termination was not due to safety concerns.”
• Risk Of Severe Hepatic Injury In Patients With Invasive Candidiasis Treated With Echinocandins
  NCT01213823 · TERMINATED · funding business
  “The study was terminated on May 5, 2011, due to methodological issues. The decision to terminate the study was not based on any safety or efficacy concerns.”
• Efficacy And Safety Of PF-00885706 For The Relief Of Symptoms In Subjects With Gastro-esophageal Reflux Disease (GERD)
  NCT00730665 · TERMINATED · regulatory
  “This study has been placed on clinical hold by the sponsor due to operational reasons.”
• A Trial Of [S,S]-Reboxetine In Patients With Chronic Painful Diabetic Peripheral Neuropathy.
  NCT00625833 · TERMINATED · futility
  “Study was terminated for futility following the planned interim analysis.”
• A 2 Week Blinded Study For Pain Due To Arthritis Of The Knee
  NCT00483977 · TERMINATED · futility
  “Met criteria for study futility at interim analysis”
• A Study To Evaluate PF-00915275 In Subjects With Type 2 Diabetes Mellitus For 4-Weeks
  NCT00427401 · TERMINATED · manufacturing supply
  “This study was terminated May 7, 2007. The study stopped due to tablet formulation issues. No safety issues were involved in the termination decision.”
• Neoadjuvant Colorectal Cancer With Unresectable Liver Metastases
  NCT00106054 · TERMINATED · futility
  “After 1 year only 2 subjects enrolled and treated thus no meaningful efficacy analyses could be performed.”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.