Heart Failure

Why trials studying Heart Failure stopped, in this sample of ClinicalTrials.gov.

50 stopped trials with a clear reason; 96% ended for non-scientific reasons.

Trials

• A Proof-of-concept Trial for OPC 131461 in Patients Hospitalized for Worsening Heart Failure
  NCT06795399 · WITHDRAWN · slow accrual
  “No sites were initiated, no sites were activated, no patients were enrolled in this study.”
• Senescence in Myocardial Infarction
  NCT07693712 · TERMINATED · funding business
  “Staffing challenges and subsequent withdrawal of funding.”
• Ultrafiltration Versus IV Diuretics in Worsening Heart Failure
  NCT05318105 · TERMINATED · funding business
  “The study was stopped early due to slow enrollment and was a business decision. This decision was not based on any efficacy or safety concerns.”
• Randomized Controlled Pilot Trial of DASH Feeding in Older Low Socioeconomic Adults Without Heart Failure
  NCT04113291 · WITHDRAWN · funding business
  “Insufficient funding”
• Portal Vein Flow Variability to Quantify Right-Sided Hemodynamic Congestion (PORTAL)
  NCT05411263 · TERMINATED · slow accrual
  “Poor recruitment”
• Analysis of Cardiac Biomarker Racial Discrepancies
  NCT05224557 · WITHDRAWN · logistics pi
  “PI no longer with the site”
• Aquapheresis Efficacy in Outpatients With Decompensated Heart Failure
  NCT04572867 · WITHDRAWN · logistics pi
  “Due to low enrollment, COVID-19 pandemic causing suspension of most outpatient elective procedures, and no protected research time, Dr. Gelzer Bell is unable to continue this study.”
• Medico-economic Evaluation of Therapeutic Adaptation Guided by the Soluble Suppression of Tumorigenicity 2 (sST-2) Biomarker in the Management of Patients With Acute Heart Failure
  NCT04554277 · TERMINATED · manufacturing supply
  “The inclusions were halted due to problems with the supply of the kits required for sST2 assays”
• Timing of Coronary Angiography in NSTE-ACS With ADHF
  NCT04810806 · TERMINATED · slow accrual
  “Slow enrollment”
• The Left Ventricular Assist Device (LVAD) Off or On Pump Implantation Study
  NCT04219618 · TERMINATED · manufacturing supply
  “The study was stopped because the manufacturer stopped producing the HeartWare LVAD device.”
• Randomized Evaluation and Verification of Ventricular Enhancement
  NCT03845127 · WITHDRAWN · slow accrual
  “Lack of enrollment”
• RIGENERA 2.0 Trial
  NCT02502747 · WITHDRAWN · slow accrual
  “slow enrolment”
• Optimised MultiSite Pacing Vector Study
  NCT03938090 · WITHDRAWN · regulatory
  “Severe delay in getting ethics/R\&D approval, Covid delays in initiating study and enrolment. Lack of fellow support for continuing study. After 3-4 years delay, concepts now”
• Acupuncture for Individuals With Stable Angina
  NCT02914834 · TERMINATED · logistics pi
  “Research activity halted due to the Coronavirus Disease 2019 (COVID-19) pandemic. We were obliged to stop the in-person study in March 2020 due to the mandated lockdowns as a result of COVID.”
• Efficacy of Omega-3 Fatty Acid Therapy in Preventing Gastrointestinal Bleeding in Patients With CF-LVAD
  NCT03784963 · TERMINATED · slow accrual
  “Low enrollment”
• Safety and Tolerability Study of AZD4831 in Patients With Heart Failure.
  NCT03756285 · TERMINATED · funding business
  “A decision was made to stop the study early when AstraZeneca evaluated the available data and it was considered that completing the study would provide limited additional information and unlikely to change the study conclusions.”
• Home-Based Fluid Status Monitoring in Heart Failure Patients
  NCT04013373 · TERMINATED · logistics pi
  “Covid-19 pandemic”
• The Effect of Nicotinamide Riboside on Skeletal Muscle Function in Heart Failure Subjects
  NCT03565328 · TERMINATED · slow accrual
  “Slow/insufficient accrual and investigators have left the study.”
• Correlation Between Peripheral Venous Pressure and Central Venous Pressure in the Cardiac Intensive Care Unit
  NCT03526497 · TERMINATED · slow accrual
  “Poor enrollment”
• e-Diary in Heart Failure
  NCT03452683 · WITHDRAWN · slow accrual
  “Competing trials”
• Optimal Balance Alfapump® System Feasibility Study
  NCT03032211 · WITHDRAWN · funding business
  “Change in company strategy”
• Nitroglycerin vs. Furosemide Using Lung Ultrasound Pilot Trial
  NCT03259165 · TERMINATED · logistics pi
  “COVID-19 pandemic. Initially had planned to resume study, but ultimately decided to close.”
• Phrenic Nerve Stimulation for Treatment of Central Sleep Apnea
  NCT03238937 · WITHDRAWN · slow accrual
  “No eligible subjects were identified.”
• Subcu Administration of CD-NP in Heart Failure Patients With Left Ventricular Assist Device Support
  NCT03091998 · WITHDRAWN · funding business
  “No funding available”
• Study to Evaluate the Safety and Tolerability of AMG 986 in Healthy Volunteers and Heart Failure Patients
  NCT03276728 · TERMINATED · funding business
  “Terminated (Decision by the Sponsor. The study was not terminated due to a safety reason.)”
• Pharmacist Role in HF Patients Transition of Care
  NCT02874183 · WITHDRAWN · regulatory
  “Collaborating site had difficulty with approval”
• Nursing Therapeutics Education and Heart Failure (HF): a Study Protocol
  NCT02425488 · TERMINATED · funding business
  “Feasability phase completed: Cost Evaluation”
• Effects of Treating Sleep Apnea in Patients With Congestive Heart Failure
  NCT01997866 · WITHDRAWN · slow accrual
  “Re-evaluate inclusion/exclusion criteria”
• Sentus QP - Extended CRT Evaluation With Quadripolar Left Ventricular Leads
  NCT02290028 · TERMINATED · regulatory
  “BIOTRONIK received FDA approval to transition the ongoing Sentus QP Study to a new EP PASSION real-world data methodology.”
• Clinical Trial to Evaluate the the ReliantHeart HeartAssist 5® VAD System in Patients Awaiting Heart Transplantation
  NCT02205411 · TERMINATED · slow accrual
  “Inability to timely enroll.”
• HF Assessment With BNP in the Home: Part II
  NCT02351063 · TERMINATED · funding business
  “Sponsor's discretion to terminate study prematurely for further evaluation.”
• Discharge Counseling and Medication Therapy Management (MTM) Services After Discharge for Heart Failure Patients
  NCT01822171 · TERMINATED · slow accrual
  “Unable to enroll and study intended patient population.”
• The Use of CoSeal (Sealant Agent) in Patients During Left Ventricular Assist Device Surgery
  NCT01605019 · TERMINATED · funding business
  “funding for study stopped”
• Right Ventricular (RV) Pacing in Early Post-operative Continuous Flow Left Ventricular Assist Device (LVAD)
  NCT01446796 · TERMINATED · slow accrual
  “Recruitment futility”
• Intra-coronary Versus Intramyocardial Application of Enriched CD133pos Autologous Bone Marrow Derived Stem Cells
  NCT01337011 · TERMINATED · funding business
  “study was stopped due to funding issues”
• Harvest, Isolation and Culture of Cardiac Stem Cells From Endomyocardial Biopsies
  NCT01576757 · WITHDRAWN · funding business
  “There were no funds for the study.”
• Endocardial Pacing in On-table Non-responders in Cardiac Resynchronization Therapy
  NCT01193712 · WITHDRAWN · slow accrual
  “too limited number of eligible patients”
• Effect of Adaptive Servo Ventilation (ASV) on Survival and Hospital Admissions in Heart Failure
  NCT01128816 · TERMINATED · safety
  “Philips Global Field Safety Notice for PAP Devices \& Ventilators, June 14, 2021 (June 15, 2021 censor date for trial). Patient final visits and collection of endpoints prior to censor date continued to March 31, 2022.”
• Assessing the Safety/Efficacy of Transdermal Testosterone in Female Patients With Symptomatic Heart Failure
  NCT00957034 · TERMINATED · slow accrual
  “Due to difficult patient enrollment.”
• Phase I Interaction Study of Istaroxime and Digoxin in Subjects With Stable Heart Failure
  NCT00869115 · WITHDRAWN · funding business
  “The study was not started due to a re-evaluation of the istaroxime development program”
• Safety and Efficacy Study of Add On Aliskiren in Patients With Heart Failure and Renal Impairment
  NCT00881439 · TERMINATED · futility
  “Futility”
• Therapeutic Education by Telemedicine in Chronic Heart Failure
  NCT00878202 · TERMINATED · slow accrual
  “Insufficient recruitment”
• PAF-HEFT (Permanent Atrial Fibrillation in Heart Failure Trial)
  NCT00839566 · TERMINATED · slow accrual
  “Number of eligible patients too small.”
• Correlation Of Respiratory Rate Level And Trend Evaluation in Heart Failure Patients
  NCT00758121 · TERMINATED · funding business
  “Inappropriate therapy associated with certain right ventricular (RV) lead complications may occur more frequently if the Respiratory Sensor is programmed On”
• A Novel Echocardiography Modality to Assess Left Ventricular Dyssynchrony
  NCT01007981 · WITHDRAWN · logistics pi
  “investigator left the institution”
• Placement of CS/LV Pacing Leads With EnSite NavX Guidance
  NCT00577187 · WITHDRAWN · slow accrual
  “Lack of enrollment”
• Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure
  NCT00608140 · TERMINATED · slow accrual
  “Unable to recruit sufficient numbers of patients.”
• Role of Natriuretic Peptides in the Treatment of Acutely Decompensated Heart Failure Patient With Obstructive Airways Disease
  NCT00562692 · TERMINATED · slow accrual
  “Recruitment very difficult. Study drug expired so we have stopped the study.”
• Serial BNP Testing for Heart Failure Management
  NCT00622531 · TERMINATED · slow accrual
  “Study terminated due to insufficient enrollment”
• Study of High Dosage of Losartan in Comparison to Low Dose of Losartan in Heart Failure Patients
  NCT02238457 · WITHDRAWN · slow accrual
  “Difficulty recruiting patients”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.