Autopsy report · NCT03523767

Effect of Systemic Inflammation on Emotion and Cognition in Patients With Mood Disorder - A Vaccine Study

“Early termination related to COVID pandemic”

The sponsor’s own words in the registry.

Life of this trial

• Registered 3 months after it had already started.
• Ran for about 2 years before it stopped.
• 19 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 1

Sponsor

The University of Texas Health Science Center, Houston

Sponsor type

University, hospital or other

Conditions

Major Depressive Disorder

Interventions

S.typhi Injection; Normal Saline Injection

Participants

19

Sites

1

Countries

United States

Trials that died the same way

• OptiVol for Precision Medical Management of Heart Failure
  “Early termination due to COVID Pandemic” (98% match in meaning)
• Measurement of the Partial Pressure of Oxygen in Cutaneous Tumors Using Electron Paramagnetic Resonance (EPR) Oximetry
  “Terminated March 22, 2022 due to COVID-19 pandemic” (75% match in meaning)
• Evaluation of Skin Cleansers and Skin Protectants in Management of Incontinence-associated Dermatitis
  “Early termination due to COVID-19 pandemic led to inability to reach planned sample size” (73% match in meaning)
• A Study to Learn About the Medicine Called Nirmatrelvir Used in Combination With Ritonavir in People With Weakened Immune Systems or at Increased Risk for Poor Outcomes Who Are Hospitalized Due to Severe COVID-19
  “Termination due to challenges related to the operational feasibility of the study, taking into account the current epidemiology and declining hospitalization rates for severe COVID-19.” (72% match in meaning)
• Optune Device - TT Field Plus Nivolumab and Ipilimumab for Melanoma With Brain Metastasis
  “The study was terminated early on 03/09/2022 due to low accrual during the COVID-19 pandemic.” (71% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.