Major Depressive Disorder

Why trials studying Major Depressive Disorder stopped, in this sample of ClinicalTrials.gov.

34 stopped trials with a clear reason; 88% ended for non-scientific reasons.

Trials

• Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV
  NCT06705478 · SUSPENDED · slow accrual
  “Temporarily Closed (Paused) to Accrual”
• N2O for Acute Suicidality and Depression in the ED
  NCT05710887 · WITHDRAWN · logistics pi
  “PI has left the university”
• Low-Intensity Focused Ultrasound for Treatment-Resistant Depression
  NCT06013384 · SUSPENDED · logistics pi
  “Study PI left institution and there is currently no one else available to run the study.”
• Randomized, Double-Blind, Placebo-Controlled Trial of REL-1017 as Adjunctive Treatment for MDD
  NCT06011577 · TERMINATED · safety
  “Study REL-1017-304 was terminated early by the Sponsor following the prespecified interim analysis for sample size re-estimation conducted in study REL-1017-302. Safety assessments were performed in both studies in accordance with the study protocols”
• PET Synaptogenesis After Psilocybin In DEpression Recovery
  NCT05601648 · WITHDRAWN · futility
  “Due to negative results in similar trials using 11C-UCB-J”
• Digital Therapeutic for Adolescent Depressive Symptoms in Cardiology and Gastroenterology
  NCT05461599 · TERMINATED · slow accrual
  “Enrollment too low”
• Neurobiology of Treatment Responses in MDD
  NCT03068247 · WITHDRAWN · manufacturing supply
  “Institution was unable to manufacture radiotracer that was central to the protocol. Study transferred to another institution.”
• Antidepressant Effects of TS-161 in Treatment-Resistant Depression
  NCT04821271 · TERMINATED · slow accrual
  “due to low recruitment”
• Antidepressant Response in Older Adults With Comorbid PTSD and MDD
  NCT04697693 · TERMINATED · logistics pi
  “Unable to recruit participants in a timely fashion due to COVID pandemic”
• Cognitive Behavioral Therapy Group for Older Adults Delivered by Telethealth
  NCT04714164 · TERMINATED · slow accrual
  “We had difficulty with participation in the study for our initial Zoom CBT group.”
• Neuroinflammation, Affective and Cognitive Symptoms in Major Depression and Psoriasis
  NCT04423471 · WITHDRAWN · funding business
  “Lack of funding”
• Leveraging EEG for Antidepressant Prediction With Duloxetine and Bupropion
  NCT04388189 · WITHDRAWN · slow accrual
  “No participants enrolled”
• Treatment of Major Depressive Disorder in the UK Using TMS Therapy
  NCT04217837 · WITHDRAWN · logistics pi
  “COVID”
• Does rTMS Induce Synaptic Plasticity?
  NCT04311619 · WITHDRAWN · funding business
  “We did not receive grant funding for this study.”
• Waitlist-Control Trial of Smartphone CBT for Major Depressive Disorder (MDD), Withdrawn
  NCT03769350 · WITHDRAWN · other
  “Study must be registered under the sponsor instead of the site, so we have created a new posting in the sponsor's account.”
• Cognition in Mindfulness: Negativity and Depression
  NCT05802966 · TERMINATED · funding business
  “No (financial) means left to continue inclusion to achieve predetermined sample size. Instead of continuation (high probability of unanalyzed data) it was decided to stop inclusion and analyze data, so the scientific community can benefit from it.”
• The Role of HNKs in the Antidepressant Effect of Ketamine
  NCT03977675 · TERMINATED · logistics pi
  “PI left the institution”
• Glabellar Botulinum Toxin Injections for the Treatment of Geriatric Depression
  NCT03833063 · WITHDRAWN · slow accrual
  “recruitment difficulties due to COVID19”
• Modafinil's Effects on Cognition in Remitted MDD
  NCT03620253 · TERMINATED · logistics pi
  “Principal Investigator left study site”
• Rapid Antidepressant Effects of Leucine
  NCT03079297 · TERMINATED · logistics pi
  “Covid-19”
• Vortioxetine in Patients With Major Depressive Disorder and Coronary Artery Disease
  NCT02454426 · WITHDRAWN · logistics pi
  “PI left institution”
• Enhancing Psychotherapy for Mood Disorders With Whole Body Hyperthermia
  NCT02021149 · TERMINATED · logistics pi
  “Investigator transferred to the University of Wisconsin - Madison”
• Chronotherapy Randomized Controlled Trial
  NCT02176824 · TERMINATED · logistics pi
  “PI”
• A Study to Investigate Evoked Potentials as Markers of Ketamine-induced Cortical Plasticity in Patients With Major Depressive Disorder
  NCT01957410 · TERMINATED · futility
  “Clinical Team decision to terminate the study after the results from Cohort 1 did not support conducting Cohort 2.”
• A Comparison of Medication Augmentation and PST in the Treatment of Depression in Older Adults
  NCT01942187 · WITHDRAWN · slow accrual
  “No participants enrolled.”
• The Effects of Vilazodone on Glutamate in the Anterior Cingulate Cortex in Anxious Unipolar Depressives
  NCT02028026 · WITHDRAWN · slow accrual
  “Inability to recruit eligible subjects”
• Investigate Efficacy & Safety of RO4995819 vs. Placebo as Adjunct Tx in Patients w/Major Depressive Disorder
  NCT01733654 · WITHDRAWN · slow accrual
  “no participants enrolled”
• Study of Placebo Without Deception Versus Standard Antidepressant for Major Depressive Disorder
  NCT01650740 · TERMINATED · slow accrual
  “Poor recruitment results.”
• Potential Use Of Brain Network Activation Analysis to Diagnose Major Depression
  NCT01579942 · TERMINATED · funding business
  “The study was ultimately not funded by the sponsor. No subjects were enrolled.”
• ON/OFF Stimulation and Impulsivity in Patients With Deep Brain Stimulators
  NCT01506206 · WITHDRAWN · funding business
  “Study was not funded and never enrolled participants.”
• Efficacy and Safety Study of ABT-436 in Major Depressive Disorder
  NCT01741142 · TERMINATED · funding business
  “Decision based on strategic determination; not safety.”
• Risks for Insulin Resistance and Metabolic Syndrome Between Major Depressive Disorder (MDD) or MDD With Psychotic Features
  NCT01310140 · TERMINATED · logistics pi
  “PI left Massachusetts General Hospital Inpatient service”
• Time to Remission of Depressive Symptoms With Combined SSRI and Ramelteon
  NCT00642694 · TERMINATED · funding business
  “Enrollment discontinued based on mutually agreed upon decision by PI and funding sponsor”
• Light Therapy for Elderly Depression
  NCT00332670 · TERMINATED · logistics pi
  “End of research time, time-resources”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.