Autopsy report · NCT03506373

Ibrutinib and Ixazomib Citrate in Treating Newly Diagnosed, Relapsed or Refractory Waldenstrom Macroglobulinemia

“Discontinued after interim analysis for futility; no treatment successes observed in the first 12 patients”

The sponsor’s own words in the registry.

Life of this trial

• Registered 4 months before it started.
• Ran for about 7 years 6 months before it stopped.
• 21 participants enrolled.
• Results were posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Mayo Clinic

Sponsor type

University, hospital or other

Conditions

Recurrent Waldenstrom Macroglobulinemia; Refractory Waldenstrom Macroglobulinemia; Waldenstrom Macroglobulinemia

Interventions

Ibrutinib; Ixazomib Citrate; Laboratory Biomarker Analysis; Pharmacodynamic Study; Pharmacokinetic Study

Participants

21

Sites

2

Countries

United States

Trials that died the same way

• A Study of Idasanutlin With Cytarabine Versus Cytarabine Plus Placebo in Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML)
  “The study was stopped for futility based on efficacy results at the interim analysis; no unexpected safety findings were observed.” (78% match in meaning)
• Tissue Adhesive vs. Sterile Strips After Cesarean Delivery
  “Based on results of an interim analysis, the study was halted for futility” (76% match in meaning)
• Effect of ITF2357 on Mucosal Healing in Patients With Moderate-to-severe Active Crohn's Disease
  “As no safety warnings were detected, Interim analysis from the first 40 patients recommends to stop the trial for futility” (75% match in meaning)
• Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM)
  “This trial was terminated following a futility analysis confirming futility of continuing the study” (75% match in meaning)
• Magrolimab + Azacitidine Versus Azacitidine + Placebo in Untreated Participants With Myelodysplastic Syndrome (MDS)
  “Study discontinued due to futility based on a planned analysis” (74% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.