Autopsy report · NCT04313881

Magrolimab + Azacitidine Versus Azacitidine + Placebo in Untreated Participants With Myelodysplastic Syndrome (MDS)

“Study discontinued due to futility based on a planned analysis”

The sponsor’s own words in the registry.

Life of this trial

• Registered 6 months before it started.
• Ran for about 3 years before it stopped.
• 539 participants enrolled.
• Results were posted on the registry 6 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

Gilead Sciences

Sponsor type

Industry

Conditions

Myelodysplastic Syndromes

Interventions

Magrolimab; Azacitidine; Placebo

Participants

539

Sites

169

Countries

Australia, Austria, Belgium, Canada, Czechia, Finland, France, Germany, Hong Kong, Hungary, Italy, Netherlands and more

Trials that died the same way

• Study of Magrolimab in Combination With Azacitidine Versus Physician's Choice of Venetoclax in Combination With Azacitidine or Intensive Chemotherapy in Patients With TP53 Mutant Acute Myeloid Leukemia That Have Not Been Treated
  “Study discontinued due to futility.” (89% match in meaning)
• Study of Nintedanib and Chemotherapy for Advanced Pancreatic Cancer
  “The study was terminated due to futility and lack of future funding” (84% match in meaning)
• Pembrolizumab (MK-3475) Versus Placebo Following Surgery and Radiation in Participants With Locally Advanced Cutaneous Squamous Cell Carcinoma (MK-3475-630/KEYNOTE-630)
  “The study stopped due to futility” (84% match in meaning)
• Comparison Between Radiofrequency and Balloon Compression in the Treatment of Idiopathic Trigeminal Neuralgia
  “Study halted due to futility” (84% match in meaning)
• Tissue Adhesive vs. Sterile Strips After Cesarean Delivery
  “Based on results of an interim analysis, the study was halted for futility” (83% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.