Autopsy report · NCT00973024

A Dose-ranging Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Low Back Pain

“Based on lack of efficacy in PAI2003, sponsor made the decision to discontinue the trial.”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 1 year 8 months before it stopped.
• 389 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

Sponsor type

Industry

Conditions

Low Back Pain; Low Back Pain, Recurrent

Interventions

JNJ-42160443 3 mg; JNJ-42160443 1 mg; JNJ-42160443 6 mg/3mg; JNJ-42160443 10 mg; Matching Placebo

Participants

389

Sites

60

Countries

Belgium, Canada, Netherlands, United States

Trials that died the same way

• Safety and Efficacy of MAGE-A3/A6 T Cell Receptor Engineered T Cells (KITE-718) in HLA-DPB1*04:01 Positive Adults With Advanced Cancers
  “The study was terminated due to the sponsor's decision to discontinue the clinical trial.” (79% match in meaning)
• A Dose Range Finding Study of JNJ-38518168 in Patients With Active Rheumatoid Arthritis in Spite of Treatment With Methotrexate
  “The decision was made to prematurely discontinue this trial due to lack of efficacy.” (78% match in meaning)
• TAS-117 in Patients With Advanced Solid Tumors Harboring Germline PTEN Mutations
  “The Sponsor had decided to terminate this clinical trial due to an insufficient rate of accrual of patients.” (76% match in meaning)
• Study of Avatrombopag for Temozolomide-induced Thrombocytopenia in Glioma (APATIT-G)
  “PI and Sponsor decided to not proceed with the trial.” (74% match in meaning)
• A Phase 2a Pharmacodynamic Study of TAK-448 in Participants With Hypogonadotropic Hypogonadism
  “Sponsor decision to terminate the study because the study did not achieve the primary efficacy objective.” (73% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.