Autopsy report · NCT04770246

TAS-117 in Patients With Advanced Solid Tumors Harboring Germline PTEN Mutations

“The Sponsor had decided to terminate this clinical trial due to an insufficient rate of accrual of patients.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 1 month before it started.
• Ran for about 1 year 11 months before it stopped.
• 17 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 1

Sponsor

Taiho Oncology, Inc.

Sponsor type

Industry

Conditions

Advanced or Metastatic Solid Tumors Irrespective of Gene Alterations; Advanced or Metastatic Solid Tumors With Germline PTEN Inactivating Mutations

Interventions

TAS-117; TAS-117; TAS-117; TAS-117

Participants

17

Sites

8

Countries

Austria, France, United Kingdom, United States

Trials that died the same way

• Study to Determine the Safety and Efficacy of INCB018424 in Patients With Polycythemia Vera or Essential Thrombocythemia
  “Termination of the clinical trial by sponsor.” (85% match in meaning)
• Safety and Efficacy of MAGE-A3/A6 T Cell Receptor Engineered T Cells (KITE-718) in HLA-DPB1*04:01 Positive Adults With Advanced Cancers
  “The study was terminated due to the sponsor's decision to discontinue the clinical trial.” (82% match in meaning)
• An Extension of Protocol PRO 140_CD01 Study
  “FDA required the sponsor to halt enrollment in the trial and transition participants to available therapies for the treatment of their disease. The trial was subsequently terminated once participants were transitioned.” (77% match in meaning)
• Avelumab and Radiation in Muscle-Invasive Bladder Cancer
  “In agreement with the drug sponsor and the institution, the trial has been terminated due to slow accrual.” (76% match in meaning)
• A Dose-ranging Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Low Back Pain
  “Based on lack of efficacy in PAI2003, sponsor made the decision to discontinue the trial.” (76% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.