Autopsy report · NCT02369796

A Phase 2a Pharmacodynamic Study of TAK-448 in Participants With Hypogonadotropic Hypogonadism

“Sponsor decision to terminate the study because the study did not achieve the primary efficacy objective.”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 9 months before it stopped.
• 15 participants enrolled.
• Results were posted on the registry 1 year 5 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Takeda

Sponsor type

Industry

Conditions

Hypogonadotropic Hypogonadism

Interventions

TAK-448

Participants

15

Sites

1

Countries

United Kingdom

Trials that died the same way

• KN046 Plus Lenvatinib in Subject With Advanced Non-Small Cell Lung Cancer in the Failure of Anti-PD-(L)1 Agent
  “Because the efficacy data did not meet expectations, the sponsor decided to terminate the study.” (86% match in meaning)
• A Study of Lorcaserin as Adjunctive Treatment in Participants With Dravet Syndrome
  “The study was terminated by Sponsor and the decision was not due to any safety or efficacy reasons.” (85% match in meaning)
• Safety and Efficacy of MAGE-A3/A6 T Cell Receptor Engineered T Cells (KITE-718) in HLA-DPB1*04:01 Positive Adults With Advanced Cancers
  “The study was terminated due to the sponsor's decision to discontinue the clinical trial.” (82% match in meaning)
• Evaluate the Performance of JOURNEY II CR and JOURNEY II BCS in TKA Populations
  “Study design is not reasonable and sponsor decided to terminate the study. No patient enrolled by now” (81% match in meaning)
• Colorectal Lesion Evaluation and Appropriate Resolution (CLEAR) Study
  “Study terminated per sponsor decision due to operational reasons. The termination was not a result of any participant safety concerns.” (81% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.