Autopsy report · NCT05001724

KN046 Plus Lenvatinib in Subject With Advanced Non-Small Cell Lung Cancer in the Failure of Anti-PD-(L)1 Agent

“Because the efficacy data did not meet expectations, the sponsor decided to terminate the study.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 3 months before it started.
• Ran for about 1 year 5 months before it stopped.
• 16 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 2, Phase 3

Sponsor

Jiangsu Alphamab Biopharmaceuticals Co., Ltd

Sponsor type

Industry

Conditions

Advanced Non-small Cell Lung Cancer

Interventions

KN046; Lenvatinib; Docetaxel

Participants

16

Sites

1

Countries

China

Trials that died the same way

• A Phase 2a Pharmacodynamic Study of TAK-448 in Participants With Hypogonadotropic Hypogonadism
  “Sponsor decision to terminate the study because the study did not achieve the primary efficacy objective.” (86% match in meaning)
• A Study of Lorcaserin as Adjunctive Treatment in Participants With Dravet Syndrome
  “The study was terminated by Sponsor and the decision was not due to any safety or efficacy reasons.” (83% match in meaning)
• Safety Study of the VEGA UV-A System to Treat Keratoconus
  “The sponsor terminated the study prior to data analysis for financial reasons.” (82% match in meaning)
• Safety and Efficacy of MAGE-A3/A6 T Cell Receptor Engineered T Cells (KITE-718) in HLA-DPB1*04:01 Positive Adults With Advanced Cancers
  “The study was terminated due to the sponsor's decision to discontinue the clinical trial.” (82% match in meaning)
• Study of RP-6306 With FOLFIRI in Advanced Solid Tumors
  “Sponsor decided to terminate the study” (81% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.