Autopsy report · NCT01679951

A Dose Range Finding Study of JNJ-38518168 in Patients With Active Rheumatoid Arthritis in Spite of Treatment With Methotrexate

“The decision was made to prematurely discontinue this trial due to lack of efficacy.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 2 months before it started.
• Ran for about 1 year 8 months before it stopped.
• 272 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Janssen Research & Development, LLC

Sponsor type

Industry

Conditions

Rheumatoid Arthritis

Interventions

Placebo; JNJ-38518168 (3 mg); JNJ-38518168 (10 mg); JNJ-38518168 (30 mg); Methotrexate

Participants

272

Sites

85

Countries

Argentina, Chile, Colombia, Czechia, Hungary, Japan, Latvia, Mexico, Poland, Romania, Russia, South Korea and more

Trials that died the same way

• Acute Effects Of Donepezil On Brain Perfusion And Memory In Subjects With Cognitive Impairment And Mild Alzheimer's Disease
  “The study was terminated because of slow enrollment. The decision to terminate the trial was not based on any safety or efficacy concerns.” (82% match in meaning)
• A Study to Learn About the Study Medicine Called PF-08046031 in Advanced Melanoma and Other Solid Tumors
  “The trial was terminated for strategic reasons. The decision was not based on any safety and/or efficacy concerns.” (81% match in meaning)
• A Dose-finding Study of CC-90009 in Subjects With Relapsed or Refractory Acute Myeloid Leukemia or Relapsed or Refractory Higher-risk Myelodysplastic Syndromes
  “Trial terminated because of lack of efficacy in the short term acute phase.” (79% match in meaning)
• A Dose-ranging Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Low Back Pain
  “Based on lack of efficacy in PAI2003, sponsor made the decision to discontinue the trial.” (78% match in meaning)
• A Study of LY3405105 in Participants With Advanced Cancer
  “The study was terminated for lack of sufficient efficacy.” (77% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.