Rheumatoid Arthritis

Why trials studying Rheumatoid Arthritis stopped, in this sample of ClinicalTrials.gov.

35 stopped trials with a clear reason; 91% ended for non-scientific reasons.

Trials

• The Sequestration of Holistic Stress Management Techniques for Adults
  NCT06098755 · WITHDRAWN · slow accrual
  “No Participants Enrolled”
• Study of GS-0272 in Participants With Rheumatoid Arthritis
  NCT06031415 · TERMINATED · futility
  “Study terminated due to lack of efficacy.”
• MabionCD20® Compared to MabThera® and Rituxan® in Patients With Rheumatoid Arthritis
  NCT04680962 · WITHDRAWN · funding business
  “Study closed for business reasons before patient recruitment was initiated.”
• Safety and Preliminary Signs of Efficacy of F8IL10 for Intra-articular Treatment
  NCT05622175 · WITHDRAWN · other
  “Study redesigned and registered under NCT07245992 (Protocol n° PH-F8IL10INTRA-03/24)”
• Lifestyle Intervention for Rheumatoid Arthritis
  NCT05554705 · TERMINATED · logistics pi
  “Lost necessary staff support”
• Comparison of Tc 99m Tilmanocept Imaging With IHC Analysis of CD206 Expression in Synovial Tissue of Subjects With RA
  NCT04078191 · TERMINATED · funding business
  “Sponsor decision.”
• Effects of Abatacept on Myocarditis in Rheumatoid Arthritis
  NCT03619876 · TERMINATED · funding business
  “Lack of funding”
• Novel PET Radioligand as an Inflammatory Biomarker in Musculoskeletal Conditions
  NCT03912428 · TERMINATED · slow accrual
  “due to difficulty with participant recruitment and data futility”
• Effect of the Inhibitors of the Way JAK-STAT on Regulatory B Cells
  NCT03755297 · TERMINATED · slow accrual
  “Default of recruitment”
• Mesenchymal Stem Cells in Early Rheumatoid Arthritis
  NCT03186417 · TERMINATED · slow accrual
  “slow enrollment during covid and lack of funds to continue”
• Circadian RA Study in Rheumatoid Arthritis Subjects
  NCT03178955 · WITHDRAWN · funding business
  “The Investigator decided not to pursue this study.”
• Real Life Evaluation of Rheumatoid Arthritis Patients in Israel Treated With HUMIRA
  NCT02322723 · WITHDRAWN · slow accrual
  “No enrollment”
• Non-inferiority of Reduced-dose Rituximab in Rheumatoid Arthritis in Low Disease Activity and Remission
  NCT05116228 · TERMINATED · slow accrual
  “Failure to recruit”
• Research Study on the Immunosuppressive Effects of a Cell Therapy Product on PBMC Isolated From Blood of Patients With Inflammatory Rheumatic Diseases
  NCT03454932 · TERMINATED · slow accrual
  “limited number of recruited patients”
• Namilumab vs Adalimumab in Participants With Moderate to Severe Early Rheumatoid Arthritis Inadequately Responding to Methotrexate
  NCT02393378 · TERMINATED · funding business
  “Strategic decision - to understand data from psoriasis study - NCT02129777 and wait for results of formal proof of concept study - NCT02379091.”
• Effects of Lacosamide on Post-operative Opioid Requirements After a Total Hip Arthroplasty:
  NCT02342977 · WITHDRAWN · slow accrual
  “We were unable to enroll any patients into the study.”
• Abatacept vs Placebo in RA Patients With Hepatitis B on Entecavir Background
  NCT02053727 · WITHDRAWN · slow accrual
  “The study team did not enroll any patients due to difficulty with recruitment.”
• Comparison of Two Etanercept Regimens (REUMATOCEPT® Versus ENBREL®) for Treatment of Rheumatoid Arthritis
  NCT01394913 · WITHDRAWN · funding business
  “Sponsor decision”
• An Evaluation of Sarilumab Plus Methotrexate Compared to Etanercept Plus Methotrexate in RA Patients Not Responding to Adalimumab Plus Methotrexate
  NCT01764997 · TERMINATED · slow accrual
  “Due to small number of participants entering randomization. Not a safety issue.”
• Ultrasound and Withdrawal of Biological DMARDs in Rheumatoid Arthritis
  NCT01602302 · TERMINATED · slow accrual
  “low recruitment”
• Evaluation of Safety and Effectiveness of Fostamatinib Compared to Placebo in Patients in Asia With Rheumatoid Arthritis
  NCT01569074 · TERMINATED · funding business
  “AZ decision to discontinue fostamatinib development in RA; rights to fostamatinib returned to Rigel Pharmaceuticals.”
• Effect of SAR153191 (REGN88) With Methotrexate in Patients With Active Rheumatoid Arthritis Who Failed TNF-α Blockers
  NCT01217814 · TERMINATED · funding business
  “Due to delay in the study and the impact on the development timelines, not due to any identified safety concerns”
• Safety and Efficacy of AMG 827 in Subjects With RA
  NCT01059448 · TERMINATED · futility
  “Lack of efficacy for Brodalumab in Rheumatoid Arthritis (RA)”
• Dose Ranging Study of ART621 in Subjects Diagnosed With Rheumatoid Arthritis Taking Methotrexate
  NCT00928317 · TERMINATED · funding business
  “Corporate re-prioritization”
• Open-Label, Multicenter Extension Study for Patients Completing Treatment Phase of a Rigel-Sponsored R935788 Studies
  NCT00805467 · TERMINATED · funding business
  “AZ decision to discontinue fostamatinib development in RA; rights to fostamatinib returned to Rigel Pharmaceuticals.”
• Clinical Outcomes, Compliance and Effectiveness of Switching From Infliximab or Etanercept to Adalimumab in Patients With Active Rheumatoid Arthritis (RA). A Multicenter Post-Marketing Observational Study in Routine Clinical Use
  NCT01083160 · TERMINATED · slow accrual
  “The study was terminated due to low enrollment because inclusion criteria are obsolete.”
• Efficacy of the CLP® Hip - Retrospective
  NCT00764842 · TERMINATED · slow accrual
  “Enrollment and data collection insufficient to continue study.”
• Induction of Remission in RA Patients at Low Disease Activity by Additional Infliximab Therapy (Study P04644AM1) (TERMINATED)
  NCT00521924 · TERMINATED · slow accrual
  “Slow Enrollment”
• A Single Centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Ceramic-on-ceramic Bearing in Primary Total Hip Replacement
  NCT00872222 · TERMINATED · funding business
  “Study terminated early due to business reasons”
• Role of Chemokines and Proinflammatory Cytokines in Rheumatoid Synovial Pathological Changes
  NCT00845949 · WITHDRAWN · slow accrual
  “NO available budget and difficulty in recruiting”
• A Two Centre Study to Assess the Stability and Long-term Performance of the C-Stem™ AMT in a Total Primary Hip Replacement
  NCT00872573 · TERMINATED · logistics pi
  “Technical issues with RSA at main site and departure of Principal Investigator”
• Safety and Tolerability of Rituxan With Methotrexate and Etanercept or Methotrexate and Adalimumab in Patients With Active Rheumatoid Arthritis
  NCT00298272 · TERMINATED · funding business
  “Sponsor decided to end long term extension phase for business reasons unrelated to safety.”
• A Pharmacokinetic and Pharmacodynamic Study of MabThera (Rituximab) Plus Methotrexate in Patients With Rheumatoid Arthritis (RA)
  NCT00422942 · TERMINATED · slow accrual
  “Study was terminated after enrollment of 3 participants due to recruitment difficulties.”
• A Multi-centre Study to Assess the Long-term Performance of the DePuy PROXIMA™ Hip in Primary Total Hip Replacement
  NCT00208455 · TERMINATED · funding business
  “DePuy discontinued this product in 2013, the clinical program was reviewed and this Study was closed.”
• Ascension® Post- Approval Study; PyroCarbon Metacarpophalangeal Total Joint Prosthesis
  NCT02408471 · TERMINATED · funding business
  “Business Priorities”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.