Autopsy report · NCT00076804

Helping HIV Infected Patients in South Africa Adhere to Drug Regimens

“DSMB stopped trial for futility”

The sponsor’s own words in the registry.

Life of this trial

• Registered 1 year before it started.
• Ran for about 3 years 7 months before it stopped.
• 274 participants enrolled.
• Results were posted on the registry 1 year 10 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Johns Hopkins University

Sponsor type

University, hospital or other

Conditions

HIV Infections

Interventions

Directly Observed Therapy

Participants

274

Sites

1

Countries

South Africa

Trials that died the same way

• Strategies and Treatments for Respiratory Infections & Viral Emergencies (STRIVE): Shionogi Protease Inhibitor (Ensitrelvir)
  “DSMB closed due to futility.” (79% match in meaning)
• Efficacy and Safety of Novel Treatment Options for Adults With COVID-19 Pneumonia
  “DSMB advise due to high probability of futility” (77% match in meaning)
• AtRial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke
  “The DSMB halted the trial prematurely due to futility without any safety concerns.” (73% match in meaning)
• Estrogen Replacement to Reduce Risk of Neurologic Injury After Coronary Artery Bypass Graft Surgery
  “DSMB stopped the study based on conclusion of likely futility of treatment on the primary outcome.” (72% match in meaning)
• A Phase III Trial of Lorenzo's Oil in Adrenomyeloneuropathy
  “Upon recommendation of DSMB” (71% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.