HIV Infections

Why trials studying HIV Infections stopped, in this sample of ClinicalTrials.gov.

20 stopped trials with a clear reason; 80% ended for non-scientific reasons.

Trials

• ImmunoCARE: Rapid, Accurate COVID Testing to Reduce Hospitalization of Immunocompromised Individuals
  NCT05655546 · TERMINATED · regulatory
  “On May 13, 2024, the FDA released a communication that Cue Health tests should no longer be used.”
• AmbassADDOrs for Health Study
  NCT05357144 · TERMINATED · regulatory
  “Unanticipated changes to Tanzania's government oversight structure led to the premature termination of the trial.”
• A Study to Evaluate the Anti-inflammatory Effects of Letermovir (Prevymis) in Adults With Human Immunodeficiency Virus (HIV)-1 and Asymptomatic Cytomegalovirus (CMV) Who Are on Suppressive Antiretroviral Therapy, Plus Its Effect on Chronic Inflammation, HIV Persistence and Other Clinical Outcomes.
  NCT04840199 · TERMINATED · slow accrual
  “Permanently closed to screening and accrual due to futility”
• Cannabinoids in PLWHIV on Effective ART
  NCT03550352 · TERMINATED · manufacturing supply
  “expiration of study product; end of study product availability”
• Vitamin E for NASH Treatment in HIV Infected Individuals
  NCT03669133 · TERMINATED · logistics pi
  “lack of coordinator resources and lack of access to study resources during and due to the COVID pandemic”
• Evaluating the Safety and Immunogenicity of the IHV01 Protein Vaccine Primed and Co-Administered With HIV DNA CON-S Env Vaccine in Healthy, HIV-1-Uninfected Adults
  NCT03505060 · WITHDRAWN · manufacturing supply
  “One of the study products is no longer available for clinical trial use.”
• The Feasibility of Using a General Health Screen to Increase HIV Testing in Community Pharmacies
  NCT01751100 · WITHDRAWN · funding business
  “We did not receive proper funding to complete this study.”
• HIV Patients With Chronic Hepatitis C Genotype 1 Infection Who Failed Previously to Peginterferon /Ribavirin
  NCT01718301 · TERMINATED · slow accrual
  “Difficulty in patient recruitment”
• Kaletra and Maraviroc in Antiretroviral Therapy (ART)-Naive Patients (KALMAR Study)
  NCT01068873 · TERMINATED · slow accrual
  “Poor enrollment”
• Pilot Study to Assess Gut Mucosal B Cells in Individuals With HCV and HIV
  NCT01040039 · TERMINATED · logistics pi
  “Investigator left Rockefeller University”
• IMPAACT P1063: Safety and Effectiveness of Atorvastatin in HIV Infected Children and Adolescents With Hyperlipidemia
  NCT00663234 · TERMINATED · logistics pi
  “The study was prematurely discontinued due to administrative reasons.”
• HIV Viremia and Persistence in Acutely HIV-Infected Patients Treated With Darunavir/Ritonavir and Etravirine
  NCT00855413 · TERMINATED · slow accrual
  “Study halted by sponsor due to slow enrollment.”
• Immune Responses in Patients Treated With Raltegravir
  NCT00785967 · WITHDRAWN · slow accrual
  “Unexpected and severe difficulties in recruitment.”
• Can Presumptive Anthelminthic Treatment Delay the Progression of HIV in ART-naïve Patients in Rural Africa?
  NCT00817713 · TERMINATED · slow accrual
  “Terminated prematurely due to recruitment difficulties. Expansion to more study sites not planned.”
• High-dose Chemotherapy With Transplantation of Gene-modified Haematopoietic Stem Cells for HIV-positive Patients With Malignant Diseases Indicating an HSCT
  NCT00858793 · TERMINATED · safety
  “A leukaemia case was reported in patient treated with a similar vector. For safety risk we stopped recruitment”
• Raltegravir vs. Lopinavir/Ritonavir, Both in Combination With Truvada, in HIV+ Treatment Naive Individuals
  NCT00632970 · TERMINATED · slow accrual
  “no patients completed”
• Trial About Hepatic Security of Antiretroviral Treatment Based on Kaletra Versus Nevirapine in Co-infected HIV/HCV Patients
  NCT00661349 · TERMINATED · slow accrual
  “It has been impossible to achieve the number of patients defined by protocol”
• BOOST: Study of Increased Dosage of Lopinavir/Ritonavir (LPV/r)
  NCT00414284 · TERMINATED · futility
  “One subject's HIV RNA rebounded at week 12. A repeat PhenoSense GT combination resistance assay at week 12 revealed evolution in protease inhibitor resistance.”
• Investigating the Anti-Human Immunodeficiency Virus (HIV) & Anti-inflammatory Effect of Chloroquine
  NCT00308620 · TERMINATED · futility
  “Insufficient financial support; lack of efficacy for primary endpoint”
• Cellulose Sulfate (CS) Gel and HIV in Nigeria
  NCT00120770 · TERMINATED · safety
  “The study was halted in January 2007 due to safety concerns.”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.