Autopsy report · NCT06083571

Intranasal Ketorolac Trial

“The eligibility criteria within the protocol led to the exclusion of a large proportion of potential participants, thereby limiting enrollment. During the conceptualization phase, the number of eligible patients was overestimated.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 3 months before it started.
• Ran for about 2 years before it stopped.
• 41 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Washington University School of Medicine

Sponsor type

University, hospital or other

Conditions

Headache, Migraine

Interventions

Ketorolac; Prochlorperazine; Diphenhydramine

Participants

41

Sites

1

Countries

United States

Trials that died the same way

• Omission of Surgery in Clinically Low-risk HER2positive Breast Cancer With High HER2 Addiction and a Complete Response Following Standard Anti-HER2-based Neoadjuvant Therapy
  “The study was prematurely halted primarily due to low patient accrual. Despite efforts to optimize recruitment, the enrollment rate remained insufficient to meet the predefined targets, and continuation was deemed unfeasible” (69% match in meaning)
• The Effect of Thalidomide in Suppression of the Systemic Inflammatory Response Syndrome in Hemodialysis Patients
  “Low enrollment -- We could not recruit patients willing to be enrolled” (67% match in meaning)
• Real-Time Assessment of Stress and Stress Response
  “Not enough participants were willing to enroll.” (67% match in meaning)
• Shockwave ®S4 Catheter IVL to Treat Infrapopliteal Calcified Stenoses and/or Occlusions in CLTI Patients (LEGACY)
  “Low Enrollment rate: The study targeted a highly selected and complex patient population, making the identification and enrollment of eligible patients particularly challenging for all participating centers” (67% match in meaning)
• Effect of Primidone on Platelet Responsiveness in Patients Determined to be Clopidogrel Resistant
  “Inclusion/Exclusion criteria was too stringent to enroll patients at this site.” (66% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.