Autopsy report · NCT04578106

Omission of Surgery in Clinically Low-risk HER2positive Breast Cancer With High HER2 Addiction and a Complete Response Following Standard Anti-HER2-based Neoadjuvant Therapy

“The study was prematurely halted primarily due to low patient accrual. Despite efforts to optimize recruitment, the enrollment rate remained insufficient to meet the predefined targets, and continuation was deemed unfeasible”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 3 years 10 months before it stopped.
• 5 participants enrolled.
• Results were posted on the registry 1 year 6 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Fundacio Clinic Barcelona

Sponsor type

University, hospital or other

Conditions

HER2-positive Breast Cancer; Stage I Breast Cancer

Interventions

Trastuzumab and pertuzumab Subcutaneous Fixed-Dose Combination

Participants

5

Sites

1

Countries

Spain

Trials that died the same way

• Platelet Reactivity With Fentanyl, Morphine, or no Narcotic
  “The study was halted prematurely due to difficulties in recruiting a sufficient number of participants. Despite efforts to enroll eligible individuals, the recruitment goals were not met, making it infeasible to continue the study as planned.” (84% match in meaning)
• High Cut Off Dialysis in Systemic Inflammatory Response Syndrome Patients After Cardiac Surgery
  “Study halted prematurely, prior to enrollment of first patient, due to recruiting problems.” (83% match in meaning)
• Clinical Evaluation of Use of Prismocitrate 18 in Patients Undergoing Acute Continuous Renal Replacement Therapy (CRRT)
  “Study halted due to low recruitment, unrelated to safety or efficacy reasons” (80% match in meaning)
• All-On-4® Treatment Concept
  “The study stopped as the performance of the study showed insufficient patient recruitment.” (79% match in meaning)
• Revlite Laser System Compared to the Candela Alex TriVantage System Refractory Mixed Type Melasma
  “The study stopped because patient enrollment requirements were not met.” (78% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.