Autopsy report · NCT05198349

First in Human Study of M1069 in Advanced Solid Tumors

“Overarching portfolio-level review of the company's oncology pipeline resulted in early termination of the study. The study was not terminated due to safety.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 2 months before it started.
• Ran for about 1 year 5 months before it stopped.
• 15 participants enrolled.
• Results were posted on the registry 2 years 8 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 1

Sponsor

EMD Serono Research & Development Institute, Inc.

Sponsor type

Industry

Conditions

Metastatic or Locally Advanced Unresectable Solid Tumors

Interventions

M1069

Participants

15

Sites

3

Countries

Canada, United States

Trials that died the same way

• An Evaluation Of PF-03715455 In Moderate To Severe Uncontrolled Asthma
  “The termination was due to business reasons. No safety or efficacy concerns contributed to the termination of the study” (65% match in meaning)
• A Study of TCD601 (Siplizumab) in New Onset Type 1 Diabetes Patients
  “The study has been early terminated due to business reasons. This decision is not related to any safety, efficacy, or regulatory concerns.” (63% match in meaning)
• Study To Determine The Pharmacokinetics Of Sulfasalazine In Children With Juvenile Idiopathic Arthritis
  “Study terminated on 13 April 2016 for business reasons. No safety and/or efficacy concerns contributed to the termination of the study” (61% match in meaning)
• A Study Of Inotuzumab Ozogamicin Plus Rituximab For Relapsed/Refractory Aggressive Non-Hodgkin Lymphoma Patients Who Are Not Candidates For Intensive High-Dose Chemotherapy
  “The study was terminated prematurely on May 16, 2013, for futility. No new or unexpected safety issues were identified.” (61% match in meaning)
• A Trial to Evaluate the Efficacy and Safety of PQ912 in Patients With Early AD
  “It has been made the strategic decision to terminate the study. This decision to terminate the study early is not being made for safety reasons.” (61% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.