Autopsy report · NCT04908956

Osimertinib and Locally Ablative Radiotherapy in Patients With Synchronous Oligo-metastatic EGFR Mutant NSCLC (STEREO)

“The trial struggled with low activation due to the COVID pandemic. The Steering Committee took the decision to close the accrual in the STEREO trial as of 31 October 2023. It is important to note that no safety concerns have led to this decision.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 1 year 2 months before it started.
• Ran for about 1 year 7 months before it stopped.
• 6 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

ETOP IBCSG Partners Foundation

Sponsor type

University, hospital or other

Conditions

NSCLC Stage IV; EGFR Gene Mutation

Interventions

Osimertinib; Stereotactic Body Radiation Therapy (SBRT)

Participants

6

Sites

18

Countries

Italy, Netherlands, Poland, Singapore, South Korea, Spain, Sweden, Switzerland

Trials that died the same way

• Pilot Study of Denosumab in BRCA1/2 Mutation Carriers Scheduled for Risk-Reducing Salpingo-Oophorectomy
  “it was decided that due to lack of accrual on the trial, and low potential for accruing over the near future, the trial will be shut down.” (62% match in meaning)
• Loncastuximab Tesirine for the Treatment of Relapsed or Refractory B-Cell Malignancies
  “The trial closed early due to slow accrual.” (62% match in meaning)
• A Dose Range Finding Study of JNJ-38518168 in Patients With Active Rheumatoid Arthritis in Spite of Treatment With Methotrexate
  “The decision was made to prematurely discontinue this trial due to lack of efficacy.” (60% match in meaning)
• PERSEUS-PS Randomized Controlled Trial
  “The trial prematurely terminated as a result of the COVID-19 pandemic.” (59% match in meaning)
• Optimal Endoscopic Suturing Pattern for Esophageal Stent Fixation
  “Accrual difficulties: This trial was initiated prior to COVID-19 and interrupted by the pandemic for a significant length of time.” (58% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.