Autopsy report · NCT05453396

Loncastuximab Tesirine for the Treatment of Relapsed or Refractory B-Cell Malignancies

“The trial closed early due to slow accrual.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 1 year 1 month before it started.
• Ran for about 2 years 9 months before it stopped.
• 11 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

University of Washington

Sponsor type

University, hospital or other

Conditions

Recurrent B-Cell Non-Hodgkin Lymphoma; Recurrent Diffuse Large B-Cell Lymphoma; Recurrent Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Refractory B-Cell Non-Hodgkin Lymphoma; Refractory Diffuse Large B-Cell Lymphoma

Interventions

Loncastuximab Tesirine; Bone Marrow Biopsy; Bone Marrow Aspiration

Participants

11

Sites

1

Countries

United States

Trials that died the same way

• Myloablative Cord Blood Transplant in Haematological Malignancies (MAC UCBT)
  “Trial closed early due to poor recruitment” (77% match in meaning)
• Copanlisib in Combination With T-DM1 in Pretreated Unresectable Locally Advanced or Metastatic HER2-positive Breast Cancer
  “Accrual rate to date was too low to finish the trial in a reasonable timeframe” (77% match in meaning)
• Impact of Molecular Testing on Improved Diagnosis, Treatment and Management of CAP
  “The trial was stopped earlier than planned after an ad hoc interim analysis” (77% match in meaning)
• Pilot Study of Denosumab in BRCA1/2 Mutation Carriers Scheduled for Risk-Reducing Salpingo-Oophorectomy
  “it was decided that due to lack of accrual on the trial, and low potential for accruing over the near future, the trial will be shut down.” (76% match in meaning)
• Imatinib Mesylate and Gemcitabine in Treating Patients With Locally Advanced, Metastatic, or Recurrent Pancreatic Cancer
  “Closed to accrual to allow enrollment on another more promising trial.” (73% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.