Autopsy report · NCT04858425

Safety and Efficacy of Niclosamide in Patients With COVID-19 With Gastrointestinal Infection

“The termination of the study was a decision based on topline data analysis (no efficacy as per Day 43) of the study data.”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 2 years 4 months before it stopped.
• 166 participants enrolled.
• Results were posted on the registry 10 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Entero Therapeutics

Sponsor type

Industry

Conditions

Covid19

Interventions

Niclosamide; Placebo

Participants

166

Sites

25

Countries

India, Ukraine, United States

Trials that died the same way

• GSK1572932A Antigen-Specific Cancer Immunotherapeutic as Adjuvant Therapy in Patients With Non-Small Cell Lung Cancer
  “The study was terminated following assessment of the lack of efficacy of the study product by the Independent Data monitoring Committee for the study.” (72% match in meaning)
• An Evaluation Of PF-03715455 In Moderate To Severe Uncontrolled Asthma
  “The termination was due to business reasons. No safety or efficacy concerns contributed to the termination of the study” (71% match in meaning)
• KN046 Plus Lenvatinib in Subject With Advanced Non-Small Cell Lung Cancer in the Failure of Anti-PD-(L)1 Agent
  “Because the efficacy data did not meet expectations, the sponsor decided to terminate the study.” (68% match in meaning)
• Surgical Treatment of Chronic Neuropathic Pain
  “The study was terminated due to lower than expected enrollment. The decision to terminate the study was not based on any safety or efficacy concerns.” (68% match in meaning)
• Platform Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With aOX40 (GSK3174998) in Participants With RRMM
  “The study was terminated due to lack of efficacy.” (67% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.