Covid19

Why trials studying Covid19 stopped, in this sample of ClinicalTrials.gov.

38 stopped trials with a clear reason; 87% ended for non-scientific reasons.

Trials

• Perceptions of Undergraduate Students and Teaching Staff on Online Teaching
  NCT04466371 · SUSPENDED · logistics pi
  “Administrative problems”
• COVID-FIS: Pilot in COVID-19 (SARS-CoV-2) of Fisetin in Older Adults in Nursing Homes
  NCT04537299 · TERMINATED · futility
  “The DSMB and NIA determined the study should be stopped due to futility.”
• Data-driven Approaches to Healthcare Provider Resilience & Burnout During COVID-19
  NCT04922632 · TERMINATED · funding business
  “Funding was exhausted”
• Reconditioning Exercise for COVID-19 Patients Experiencing Residual sYmptoms
  NCT04958161 · WITHDRAWN · slow accrual
  “Unable to enroll anyone.”
• Leidos-Enabled Adaptive Protocol (LEAP-CT) for Evaluation of Post-exposure Prophylaxis for Newly-infected COVID-19 Patients
  NCT05077969 · TERMINATED · slow accrual
  “Low recruitment”
• Study of Intravenous COVI-MSC for Treatment of COVID-19-Induced Acute Respiratory Distress
  NCT04903327 · TERMINATED · slow accrual
  “Due to considerably slow enrollment, unable to reach enrollment targets”
• Enabling Family Physicians to Reduce Vaccine Hesitancy and Increase Covid-19 Vaccine Uptake
  NCT04963790 · TERMINATED · slow accrual
  “Unable to recruit enough sample size for the RCT”
• SARS-Cov-2 (COVID-19) Nasal Pharyngeal and Oral Pharyngeal Wash (SNOW) Trial
  NCT04802408 · TERMINATED · logistics pi
  “technical difficulties in sample analysis”
• A Phase 2b Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study, Evaluating Efficacy and Safety of Allocetra-OTS in Patients With Severe or Critical COVID-19 With Associated Acute Respiratory Distress Syndrome (ARDS)
  NCT04922957 · TERMINATED · funding business
  “strategic reprioritization”
• Pilot Study to Evaluate the Safety, Tolerability, and Efficacy of 5-ALA-Phosphate + SFC as an Immune System Enhancer Along With Vaccination Against COVID-19
  NCT04854876 · WITHDRAWN · regulatory
  “The food supplement/health product registration needs to be undertaken with NHRA- Pharmaceutical Product Regulations Department”
• Efficacy of Montelukast in Mild-moderate Respiratory Symptoms in Patients With Long-COVID-19:
  NCT04695704 · TERMINATED · logistics pi
  “The incidence of respiratory Long COVID has decreased in the new waves, thus made impossible to achieve the required study sample.”
• LLLT Treatment of Lung Inflammation in COVID-19
  NCT04524715 · WITHDRAWN · regulatory
  “Based upon feedback from IRB.”
• Remote Monitoring of COVID-19 Positive Outpatients
  NCT04853108 · TERMINATED · funding business
  “The study terminated early due to end of funding.”
• A Study of Inhaled Ampion in Adults With Respiratory Distress Due to COVID-19
  NCT04868890 · TERMINATED · funding business
  “The AP-019 study was prematurely terminated by the sponsor after determining that insufficient events were occurring to analyze the primary endpoint.”
• The DAWN Antivirals Trial for Ambulatory COVID-19 Patients
  NCT04730206 · TERMINATED · slow accrual
  “recruitment was too slow”
• Treatment of Respiratory Complications Associated With COVID-19 Using Umbilical Cord Mesenchymal Stromal Cells
  NCT04869397 · TERMINATED · slow accrual
  “DSMB advised discontinuing the study prematurely because recruitment goals were not achieved.”
• Nebulized Heparin for COVID19-associated Acute Respiratory Failure
  NCT04842292 · TERMINATED · slow accrual
  “Lack of enrollment”
• Performance Study of SONA Saliva C-19 Rapid Test
  NCT04877002 · TERMINATED · slow accrual
  “Limited participants”
• COVID-19: A Study to Evaluate Safety, Reactogenicity and Immunogenicity of the SARS-CoV-2 mRNA Vaccine CVnCoV in Adults With Co-morbidities
  NCT04860258 · TERMINATED · safety
  “The Principal Investigators and CureVac decided to terminate the trial early following a change to the risk/benefit profile.”
• AirFLO2 Treatment for Hypoxia and/or Tachypnea in Patients With COVID-19
  NCT04649775 · TERMINATED · slow accrual
  “no eligible participants”
• P-Co-Li (Pulmonary Covid-19 Study)
  NCT04782700 · WITHDRAWN · slow accrual
  “Due to recruitment we decided to withdraw the study.”
• Pilot Trial of XFBD, a TCM, in Persons With COVID-19
  NCT04810689 · TERMINATED · futility
  “Futile Enrollment”
• COVID-19 Oral and Subcutaneous Vaccination Using a 2nd Generation (E1/E2B/E3-Deleted) Adenovirus Platform in Healthy Volunteers in USA
  NCT04732468 · TERMINATED · slow accrual
  “The study was terminated early due to low enrollment.”
• Sensitivity of Frequent SARS-CoV-2 (COVID-19) Rapid Antigen Testing Regimen
  NCT04805840 · TERMINATED · slow accrual
  “Difficulty with recruitment.”
• Use of Hypochlorous Acid as Prophylaxis in Health Personnel at High Risk of Infection by SARS-CoV 2 (COVID19)
  NCT04684550 · WITHDRAWN · funding business
  “The study did not achieve funding or approval by the ethics committee. Once the vaccination phase was entered, the study lost validity and was not viable”
• Camostat With Bicalutamide for COVID-19
  NCT04652765 · TERMINATED · funding business
  “PI Decision to close/stop the study due to no new accrual.”
• Understanding Immunology and Patient Outcomes of COVID-19 in Hospitalized Patients
  NCT04892797 · TERMINATED · funding business
  “Grant application to fund this work was not funded. We won't be posting data for this study.”
• Steam Inhalations in COVID-19 Patients
  NCT04743349 · TERMINATED · slow accrual
  “Difficulties in enrollment”
• Mental Health Consequences of COVID19 Infection in the French RMD Cohort
  NCT04510467 · TERMINATED · slow accrual
  “inclusion number not reached during the period”
• A Trial Evaluating the Safety and Effects of an RNA Vaccine ARCT-021 in Healthy Adults
  NCT04668339 · TERMINATED · funding business
  “A decision was made to terminate the study for operational/business reasons. The study was not terminated for reasons of safety or immunogenicity.”
• Operative vs Non-Operative Management of Acute Appendicitis and Acute Cholecystitis in COVID-19 Positive Patients
  NCT04748120 · TERMINATED · slow accrual
  “Insufficient eligible patients”
• A Study to Evaluate Rapid Throughput Screening for Human COVID-19 Infection
  NCT04725097 · TERMINATED · other
  “Interim analysis indicated adaptions may be required.”
• Proxalutamide Treatment for COVID-19 Female Outpatients
  NCT04853134 · WITHDRAWN · other
  “This study was combined with another study”
• Trial of Famotidine & N-Acetyl Cysteine for Outpatients With COVID-19
  NCT04545008 · TERMINATED · slow accrual
  “Study was stopped due to poor accrual.”
• Safety and Efficacy of Dapansutrile for Treatment of Moderate COVID-19 Symptoms and Evidence of Early Cytokine Release Syndrome
  NCT04540120 · TERMINATED · logistics pi
  “Terminated due to the treatment environment for COVID-19 evolving with the pervasiveness of vaccinations and other therapeutic modalities in mitigating against severe infection that has eliminated a viable patient population for study enrollment.”
• Safety and Efficacy of EDP1815 in the Treatment of Patients Hospitalized With COVID-19 Infection
  NCT04488575 · TERMINATED · slow accrual
  “Insufficient study defined patient population”
• Changes in Cellular Immune Profile During COVID-19 Infection
  NCT04470999 · SUSPENDED · logistics pi
  “Study suspended due to the move of clinical trial site. It will be resumed when the move is complete.”
• RescuE pLAsma eXchange in Severe COVID-19
  NCT04685655 · TERMINATED · logistics pi
  “Low numbers of severe COVID-19 cases with current variants.”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.