Autopsy report · NCT04815967

Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity

“Company/sponsor business decision; not due to or related to any safety concerns”

The sponsor’s own words in the registry.

Life of this trial

• Registered 9 months before it started.
• Ran for about 1 year 6 months before it stopped.
• 32 participants enrolled.
• Results were posted on the registry 3 years 1 month after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2, Phase 3

Sponsor

Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC

Sponsor type

Industry

Conditions

Spasticity; Cerebrovascular Accident; Multiple Sclerosis; Traumatic Brain Injury; Cervical Spinal Cord Injury; Cerebral Palsy

Interventions

Phase 2; Low Dose MYOBLOC (10,000 Units); Phase 2; High Dose MYOBLOC (20,000 Units); Phase 2; Placebo; Phase 3; MYOBLOC; Phase 3; Placebo

Participants

32

Sites

9

Countries

Hungary, Poland, United States

Trials that died the same way

• (Concerto) Study of BLU-451 in Advanced Cancers With EGFR Exon 20 Insertion Mutations
  “Sponsor decision, not related to safety concerns” (86% match in meaning)
• Study of SNX281 in Subjects With Advanced Solid Tumors and Lymphoma
  “Sponsor decision (not due to safety concerns)” (84% match in meaning)
• A Evaluation of 3D Functional MIRA System in Women With Mammographically Dense Breasts
  “Sponsor decision, not safety related” (84% match in meaning)
• A 52-week, Placebo- and Active- Controlled (Roflumilast, Daliresp® 500µg) Study to Evaluate the Efficacy and Safety of Two Doses of CHF6001 DPI (Tanimilast) as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis. (PILLAR)
  “Strategic decision by Sponsor; not due to safety reasons” (84% match in meaning)
• Effect of Lixisenatide on Postprandial Lipid Profile in Obese Type 2 Diabetic Patients
  “Sponsor decision not related to safety reasons” (83% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.