Multiple Sclerosis

Why trials studying Multiple Sclerosis stopped, in this sample of ClinicalTrials.gov.

28 stopped trials with a clear reason; 82% ended for non-scientific reasons.

Trials

• Development of Digital Biomarkers in Multiple Sclerosis: Validation Study 2
  NCT06309173 · WITHDRAWN · funding business
  “The study was terminated prior to first patient enrollment based on strategic considerations.”
• A Study of End of Dose Phenomena in Subcutaneous Natalizumab Treated Multiple Sclerosis (MS) Participants
  NCT05701423 · TERMINATED · slow accrual
  “Due to low enrolment the sponsor decided to terminate the study”
• Multidimensional Integrated Assessment to Test the Efficacy and Response to Ozanimod in Multiple Sclerosis.
  NCT05777902 · TERMINATED · funding business
  “Sponsor's decision”
• Validity and Reliability of the Modified Four Square Step Test in Multiple Sclerosis Patients
  NCT05182398 · WITHDRAWN · other
  “The study was stopped because the validity and reliability study of the test method was published in the same patient group.”
• Role of Individualized Versus Traditional Exercise in Combating Fatigue
  NCT04796272 · TERMINATED · slow accrual
  “low inclusion rates”
• Assessing the Feasibility of the MSPT Device in Routine Clinical Practice in the Swiss Healthcare System
  NCT04599023 · TERMINATED · funding business
  “Decision of company to no longer develop the device.”
• Study Describing Cognitive Processing Speed Changes in Relapsing Multiple Sclerosis Subjects Treated With Ozanimod (RPC-1063)
  NCT04140305 · TERMINATED · funding business
  “Business objective has changed”
• Additional Effect of Intrapulmonary Percussive Ventilation (IPV) on Respiration in People With Multiple Sclerosis (MS).
  NCT04295616 · TERMINATED · logistics pi
  “Due to COVID-19 situation IPV is no longer allowed in the center”
• Impaired Glucose Tolerance and Cognition in MS
  NCT04748302 · TERMINATED · logistics pi
  “COVID”
• VALIDATE: Factor VIII Trending for MS Relapse
  NCT04082468 · WITHDRAWN · logistics pi
  “Never started enrollment due to logistics.”
• Physical Activity Intervention for Improving Vascular Comorbidity Risk in Multiple Sclerosis
  NCT03944538 · TERMINATED · logistics pi
  “Research restrictions and recruitment challenges due to the COVID-19 pandemic”
• Linking Cognitive Functioning to Multimodal Imaging in Multiple Sclerosis (MS)
  NCT03723356 · TERMINATED · slow accrual
  “due to low enrollment”
• Videofluoroscopic Swallowing Study (VFSS)
  NCT03387267 · TERMINATED · futility
  “Study terminated due to futility”
• Effect of MD1003 in Progressive Multiple Sclerosis (SPI2)
  NCT02936037 · TERMINATED · funding business
  “Sponsor decision for business purposes”
• Adrenocorticotropic Hormone (ACTH) Effects on Myelination in Subjects With MS
  NCT02446886 · TERMINATED · slow accrual
  “Slow enrollment”
• Online Cognitive Training in PD, MS and Depressed Patients Treated With Electroconvulsive Therapy
  NCT02525367 · TERMINATED · other
  “All Parkinson's disease patients have finished training. The MS and ECT groups have not finished as these groups had trouble including 20 patients.”
• Sleep Medical Treatment in MS Patients Suffering From Fatigue
  NCT03759249 · TERMINATED · slow accrual
  “Recruitment number could not be reached, difficult conditions under Corona”
• Fampridine Pregnancy Exposure Registry
  NCT01532154 · TERMINATED · slow accrual
  “Due to low enrollment, registration closed in agreement with the Regulatory Agency”
• Study to Evaluate Whether a Medication Event Monitoring System (MEMS) Can Improve Adherence to Tecfidera Treatment in Multiple Sclerosis Patients.
  NCT02343159 · TERMINATED · funding business
  “Sponsor Decision”
• Efficacy and Safety of AIN457 (Secukinumab) in Patients With Relapsing Multiple Sclerosis
  NCT01874340 · TERMINATED · funding business
  “Study terminated early based upon development of another anti-IL17 fully human monoclonal antibody with better potential for treating MS patients”
• Natural History of Optic Neuritis
  NCT01851434 · TERMINATED · logistics pi
  “The original analyses could not be performed due to data inconsistencies across the study sites.”
• Cytokine in Cerebrospinal Fluid (CSF) From Multiple Sclerosis Patients
  NCT01380041 · TERMINATED · other
  “Results obtained are sufficient for a publication.”
• Establishment of a Human Tissue Bank for Studying the Microbial Etiology of Neurodegenerative Diseases
  NCT01954875 · WITHDRAWN · funding business
  “Study no longer funded”
• Allogeneic Stem Cell Transplantation for the Treatment of Multiple Sclerosis
  NCT00497952 · WITHDRAWN · funding business
  “all clinical development programs terminated by sponsor”
• Aspirin for Treatment of Multiple Sclerosis-Related Fatigue
  NCT00467584 · TERMINATED · futility
  “Interim analysis indicated treatment unlikely effective;slow recruitment”
• Gene Expression in MS Patients Before and During Treatment With Interferon-beta
  NCT00202384 · TERMINATED · slow accrual
  “Few participants enrolled”
• Induction Therapy With a Single High Dose Bolus of Intravenous Methotrexate With Leucovorin Rescue, Prior to Initiation of AVONEX® Treatment, in Patients Presenting With a First Acute Demyelinating Event.
  NCT00037115 · WITHDRAWN · funding business
  “Lack of funding”
• A Trial to Investigate the Effectiveness of Testosterone Treatment in Men With Multiple Sclerosis
  NCT02317263 · WITHDRAWN · funding business
  “NIH did not fund the study so it never started”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.