Autopsy report · NCT04768348

Natural History Clinical Study in Adult PKU

“Homology Medicines has discontinued the development of this program.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 2 months before it started.
• Ran for about 2 years 3 months before it stopped.
• 7 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Sponsor

Homology Medicines, Inc

Sponsor type

Industry

Conditions

Phenylketonurias; PKU

Participants

7

Sites

8

Countries

United States

Trials that died the same way

• Evaluation of MST-188 in Acute Lower Limb Ischemia
  “Program discontinued to persue alternate indications.” (63% match in meaning)
• Study of Magrolimab in Combination With Azacitidine Versus Physician's Choice of Venetoclax in Combination With Azacitidine or Intensive Chemotherapy in Patients With TP53 Mutant Acute Myeloid Leukemia That Have Not Been Treated
  “Study discontinued due to futility.” (61% match in meaning)
• The Acute Cardiovascular Effects of Nicotine in E-cigarettes (ACE) Study
  “Study discontinued due to lack of study funding.” (59% match in meaning)
• Study of Access Site for Enhancing PCI in STEMI for Seniors (SAFE STEMI for Seniors)
  “Funding for this study has been discontinued.” (59% match in meaning)
• Efficacy and Pharmacogenomics of Cladribine Based Salvage Chemotherapy in Patients With Relapse/Refractory and Secondary Acute Myeloid Leukemia (AML) and High Risk Myelodysplastic Syndrome (MDS)
  “No longer have funding support to complete the pharmacogenetics component.” (59% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.