Autopsy report · NCT04757610

OPT-302 With Ranibizumab in Neovascular Age-related Macular Degeneration (nAMD)

“The primary endpoint was not achieved in the study.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 1 month before it started.
• Ran for about 4 years 1 month before it stopped.
• 986 participants enrolled.
• Results were posted on the registry 4 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

Opthea Limited

Sponsor type

Industry

Conditions

Neovascular Age-related Macular Degeneration

Interventions

2.0 mg OPT-302; 0.5 mg ranibizumab; Sham

Participants

986

Sites

191

Countries

Argentina, Australia, Brazil, Bulgaria, Canada, Colombia, Czechia, Denmark, France, Germany, Greece, Hungary and more

Trials that died the same way

• A Study of Ustekinumab in Participants With Active Polymyositis and Dermatomyositis Who Have Not Adequately Responded to One or More Standard-of-care Treatments
  “The study did not meet the primary endpoint.” (93% match in meaning)
• Randomized Phase 2 Trial of Axitinib and TRC105 Versus Axitinib Alone in Patients Renal Cell Carcinoma
  “The study did not meet endpoint.” (85% match in meaning)
• Phase 2 Study for SAR443820 in Participants With Amyotrophic Lateral Sclerosis (ALS)
  “The study was terminated as its Part A did not meet the primary endpoint.” (78% match in meaning)
• Study of Copanlisib in Combination With Standard Immunochemotherapy in Relapsed Indolent Non-Hodgkin's Lymphoma (iNHL)
  “Company decided to terminate this study due to study did not meet the primary endpoint.” (75% match in meaning)
• A Phase III Study to Investigate the Impact of Diamyd in Patients Newly Diagnosed With Type 1 Diabetes (EU)
  “The primary endpoint at 15 months was not met.” (73% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.