Autopsy report · NCT02626455

Study of Copanlisib in Combination With Standard Immunochemotherapy in Relapsed Indolent Non-Hodgkin's Lymphoma (iNHL)

“Company decided to terminate this study due to study did not meet the primary endpoint.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 2 months before it started.
• Ran for about 7 years 10 months before it stopped.
• 551 participants enrolled.
• Results were posted on the registry 1 year 1 month after it ended.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

Bayer

Sponsor type

Industry

Conditions

Lymphoma, Non-Hodgkin

Interventions

Copanlisib (BAY80-6946); Placebo; Rituximab; Cyclophosphamide; Doxorubicin; Vincristine

Participants

551

Sites

201

Countries

Australia, Belgium, Brazil, Bulgaria, Canada, Chile, China, Czechia, Denmark, Finland, France, Germany and more

Trials that died the same way

• Phase 2 Study for SAR443820 in Participants With Amyotrophic Lateral Sclerosis (ALS)
  “The study was terminated as its Part A did not meet the primary endpoint.” (90% match in meaning)
• A Study of Ustekinumab in Participants With Active Polymyositis and Dermatomyositis Who Have Not Adequately Responded to One or More Standard-of-care Treatments
  “The study did not meet the primary endpoint.” (82% match in meaning)
• Randomized Phase 2 Trial of Axitinib and TRC105 Versus Axitinib Alone in Patients Renal Cell Carcinoma
  “The study did not meet endpoint.” (79% match in meaning)
• OPT-302 With Ranibizumab in Neovascular Age-related Macular Degeneration (nAMD)
  “The primary endpoint was not achieved in the study.” (75% match in meaning)
• Twelve Month Clinical Evaluation of KeraSoft IC Soft Contact Lenses
  “Study was terminated due to a business decision to cancel the entire project.” (75% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.