Autopsy report · NCT04504045

Metformin's Effect on Drug Metabolism in Patients With Type 2 Diabetes

“Slow recruitment due to COVID-19, the study was stopped when recruited numbers fulfilled the pre-defined lower sample size.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 1 month before it started.
• Ran for about 1 year 8 months before it stopped.
• 10 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 1

Sponsor

University of Southern Denmark

Sponsor type

University, hospital or other

Conditions

Diabetes Mellitus, Type 2

Interventions

Metformin; Caffeine; Efavirenz; Losartan; Omeprazol; Metoprolol

Participants

10

Sites

1

Countries

Denmark

Trials that died the same way

• Mood Stabilizer (MS)+ Antidepressant vs MS + Placebo in Maintenance of Bipolar Disorder.
  “Recruitment was stopped before the planned sample size was reached owing to the Covid-19 pandemic and expiration of funding.” (86% match in meaning)
• Hypnosis for Children Undergoing Anorectal Manometry
  “Due to COVID-19 recruitement stopped since intended sample size was an estimation and not based on power calculation” (76% match in meaning)
• Riociguat in Patients With Operable CTEPH Prior to Pulmonary Endarterectomy (PEA Bridging Study)
  “The study was stopped due to slower than expected recruitment and the additional limitations on clinical research imposed by the COVID-19 pandemic, both of which made study completion within a reasonable timeframe appear unlikely.” (75% match in meaning)
• The Effect of Ovamax on Oocyte Quality
  “The study was stopped prematurely due to low recruitment rate” (75% match in meaning)
• Obesity Hypoventilation Syndrome Prevalence Study
  “This study was stopped due to low recruitment.” (75% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.