Autopsy report · NCT03273257

Riociguat in Patients With Operable CTEPH Prior to Pulmonary Endarterectomy (PEA Bridging Study)

“The study was stopped due to slower than expected recruitment and the additional limitations on clinical research imposed by the COVID-19 pandemic, both of which made study completion within a reasonable timeframe appear unlikely.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 1 year before it started.
• Ran for about 1 year 9 months before it stopped.
• 14 participants enrolled.
• Results were posted on the registry 1 year 2 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

International CTEPH Association

Sponsor type

University, hospital or other

Conditions

Chronic Thromboembolic Pulmonary Hypertension; CTEPH

Interventions

Riociguat; Placebo; Pulmonary endarterectomy

Participants

14

Sites

4

Countries

France, Germany, United Kingdom, United States

Trials that died the same way

• Effects of Community-center Based Dietary Intervention on Frailty Prevention and Regression in the Elderly.
  “Due to the impacts of COVID-19, the study had to terminate.” (80% match in meaning)
• Orthodontic Approaches to Correct Deep Bite in Mixed Dentition Patients
  “The study was terminated due to difficulties in the recruitment attributed to the Covid19 pandemic.” (80% match in meaning)
• FMT for MDRO Colonization After Infection in Renal Transplant Recipients
  “This study was paused and was not resumed due to the COVID-19 pandemic.” (80% match in meaning)
• Study to Evaluate the Efficacy and Safety of FX006 in Patients With Glenohumeral Osteoarthritis or Shoulder Adhesive Capsulitis
  “The study was terminated prematurely due to the COVID-19 pandemic creating uncertainty impacting trial progress and costs.” (79% match in meaning)
• New Formulations of Propafenone to Treat Atrial Fibrillation
  “Study halted/terminated prematurely due to COVID.” (79% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.