Autopsy report · NCT04465734

A Clinical Study to Compare the Efficacy and Safety of HLX10 in Combination With HLX04 Versus Sorafenib as the First-line Treatment in Patients With Locally Advanced or Metastatic HCC

“The trial used sorafenib as a control drug. It's not suitable now(after the A+T has been approved).The sponsor terminated the trial.”

The sponsor’s own words in the registry.

Life of this trial

• Withdrawn before it enrolled anyone. Its dates are the sponsor's plans, not events that happened.

Vital statistics

Status

Withdrawn

Phase

Phase 3

Sponsor

Shanghai Henlius Biotech

Sponsor type

Industry

Conditions

Hepatocellular Carcinoma (HCC)

Interventions

HLX10; HLX04; Sorafenib

Participants

0

Sites

1

Countries

China

Trials that died the same way

• Erlotinib in Treating Patients With Stage III or Stage IV Pancreatic Cancer
  “This study was terminated earlier due to a phase III study that showed this drug inferior to sorafenib” (71% match in meaning)
• A Study of the Safety and Pharmacokinetics of AGS-8M4 Given in Combination With Chemotherapy in Women With Ovarian Cancer
  “Trial was terminated to allow sponsors to evaluate the future development of the drug program” (71% match in meaning)
• A Phase II Study of Vemurafenib Combined With Acitretin in Patients With Advanced Melanoma
  “Pharmaceutical company pulled support for the trial.” (68% match in meaning)
• Phase IIb Clinical Trial of Recombinant Novel Coronavirus Pneumonia (COVID-19) Vaccine (Sf9 Cells)
  “Sponsor decided to cancel this trial.” (67% match in meaning)
• A Open-label Study to Assess Response to COVID-19 Vaccine in Multiple Sclerosis Participants Treated With Ofatumumab
  “Trial was terminated for business reasons. There has been no change in the benefit/risk profile of ofatumumab.” (66% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.