Autopsy report · NCT04102111

A Study Evaluating Participants With Moderately to Severely Active Crohn's Disease

“IAC completed review of futility analysis data \& determined that futility criteria were met. As a result, Janssen made decision to stop trial immediately.”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 2 years 3 months before it stopped.
• 48 participants enrolled.
• Results were posted on the registry 1 year after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Janssen Research & Development, LLC

Sponsor type

Industry

Conditions

Crohn Disease

Interventions

JNJ-67864238; Placebo

Participants

48

Sites

63

Countries

Argentina, Germany, Italy, Poland, Russia, Ukraine, United States

Trials that died the same way

• Docetaxel With or Without a Phytochemical in Treating Patients With Breast Cancer
  “The trial was stopped for futility in view of the results of the anticipated analysis” (69% match in meaning)
• Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM)
  “This trial was terminated following a futility analysis confirming futility of continuing the study” (69% match in meaning)
• Tissue Adhesive vs. Sterile Strips After Cesarean Delivery
  “Based on results of an interim analysis, the study was halted for futility” (69% match in meaning)
• CONvalescent Plasma for Hospitalized Adults With COVID-19 Respiratory Illness (CONCOR-1)
  “Study was terminated after the planned interim analysis as the pre-defined futility threshold was met” (68% match in meaning)
• A Study of Idasanutlin With Cytarabine Versus Cytarabine Plus Placebo in Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML)
  “The study was stopped for futility based on efficacy results at the interim analysis; no unexpected safety findings were observed.” (66% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.