Crohn Disease

Why trials studying Crohn Disease stopped, in this sample of ClinicalTrials.gov.

23 stopped trials with a clear reason; 87% ended for non-scientific reasons.

Trials

• EXL01 in the Maintenance of Steroid-induced Clinical Response/Remission in Participants With Mild to Moderate Crohn's Disease
  NCT05542355 · TERMINATED · slow enrollment
  “Due to low recruitment”
• Study of ExoFlo for the Treatment of Medically Refractory Crohn's Disease
  NCT05130983 · TERMINATED · slow enrollment
  “Enrollment challenges.”
• Randomized Trial Comparing Single vs. Maintenance Fecal Microbiota Transplant for Refractory Crohn's Disease in Children
  NCT03747718 · WITHDRAWN · funding or business
  “Funding”
• Whole-Food, Plant-Based Diet for Active Crohn's Disease
  NCT04982666 · WITHDRAWN · slow enrollment
  “Difficulties with recruitment and unable to enroll any subjects”
• Inflammatory Bowel Disease(IBD), Treatment Response
  NCT05350644 · TERMINATED · slow enrollment
  “Recruitment of patients for this clinical trial has been withdrawn due to logistical challenges and the inability to enroll a sufficient number of participants meeting the specific eligibility criteria within the projected timeline.”
• Personalized AZithromycin/metronidAZole Therapy in Pediatric Crohn's Disease (CD)
  NCT04186247 · TERMINATED · other
  “The DSMB concluded that feasibility endpoints were reached in time for Week 4 but no participants receiving standard of care dietary treatment could be randomized based on the at-risk of the microbiome signature.”
• PANenteric Crohn's Capsule Versus Ileo-Colonoscopy and Scan Study
  NCT04274010 · TERMINATED · slow enrollment
  “Failed to meet recruitment target due to multitude of factors (strict eligibility criteria and lack of clinician and participant engagement)”
• Mesenchymal Stem Cells for the Treatment of Perianal Fistulizing Crohn's Disease
  NCT04519671 · TERMINATED · staffing, sites or logistics
  “PI left Cleveland Clinic”
• Mesenchymal Stem Cells for the Treatment of Rectovaginal Fistulas in Participants With Crohn's Disease
  NCT04519697 · TERMINATED · staffing, sites or logistics
  “PI left Cleveland Clinic”
• Adjunctive Treatment With Vitamin D3 in Patients With Active IBD
  NCT04225819 · SUSPENDED · other
  “Protocol is being modified.”
• A Study of TAK-018 in Preventing the Recurrence of Crohn's Disease After Surgery
  NCT03943446 · TERMINATED · slow enrollment
  “Sponsor decision to discontinue study due to inability to recruit the expected number of subjects within the requisite time period.”
• A Study to Evaluate the Impact of Care4Today® IBD, a Smart System to Facilitate the Management of Crohn's Disease by Patients and Health Care Providers
  NCT04232228 · TERMINATED · drug or device supply
  “The Care4Today® IBD dashboard for HCPs and the patient app will be deactivated indefinitely and will no longer be available for use”
• The Vitamin D in Pediatric Crohn's Disease ( ViDiPeC-2 )
  NCT03999580 · TERMINATED · staffing, sites or logistics
  “Enrollment stopped at 55 of 316 planned participants due to recruitment challenges related to the COVID-19 pandemic and funding constraints. All enrolled participants completed 52-week follow-up.”
• A Study Evaluating Participants With Moderately to Severely Active Crohn's Disease
  NCT04102111 · TERMINATED · futility
  “IAC completed review of futility analysis data \& determined that futility criteria were met. As a result, Janssen made decision to stop trial immediately.”
• Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer and Pre-existing Autoimmune Disease
  NCT03656627 · TERMINATED · slow enrollment
  “low accrual”
• Cannabidiol Usage as an Adjunct Therapy for Crohn's Disease
  NCT03467620 · WITHDRAWN · funding or business
  “Inadequate funding”
• Thalidomide Versus Infliximab in New Onset Crohn's Disease With Poor Prognostic Factors
  NCT03221166 · TERMINATED · slow enrollment
  “Difficulty in recruiting subjects who meet the inclusion/exclusion criteria”
• Brief Escalation of Adalimumab Treatment for Prevention of Clinical Relapse in IBD
  NCT03059849 · WITHDRAWN · funding or business
  “lack of funding”
• A Study of Efficacy and Safety of Mongersen (GED-0301) for the Treatment of Adult and Adolescent Subjects With Active Crohn's Disease
  NCT02974322 · WITHDRAWN · funding or business
  “Sponsor decision not to start trial”
• Evaluation of the Safety, Tolerability, and Efficacy of MDGN-002 in Adults With Moderate to Severe Active Crohn's Disease or Ulcerative Colitis
  NCT03169894 · TERMINATED · funding or business
  “Strategic reasons”
• Open-Label Extension and Safety Study for Participants With Crohn's Disease Previously Enrolled in the Etrolizumab Phase III Study GA29144
  NCT02403323 · TERMINATED · funding or business
  “The study was terminated due to program discontinuation, based on mixed efficacy results in the parent studies. There were no safety concerns.”
• Effect of Increlex® on Children With Crohn Disease
  NCT00764699 · TERMINATED · staffing, sites or logistics
  “PI left institution”
• Effects of Growth Hormone in Chronically Ill Children
  NCT00286689 · WITHDRAWN · staffing, sites or logistics
  “Record Owner no longer with the institution”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.