Autopsy report · NCT03578432

Everolimus in Restoring Salivary Gland Function in Participants With Locally Advanced Head and Neck Cancer Treated With Radiation Therapy

“UACC-PHX is no longer able to support the study and Novartis is unable to provide drug beyond December 2019.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 1 month after it had already started.
• Ran for about 1 year 6 months before it stopped.
• 2 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Early Phase 1

Sponsor

University of Arizona

Sponsor type

University, hospital or other

Conditions

Salivary Gland Dysfunction; Xerostomia; Head and Neck Cancer

Interventions

Everolimus; Laboratory Biomarker Analysis; Survey Administration

Participants

2

Sites

1

Countries

United States

Trials that died the same way

• LCL161 Plus Topotecan for Patients With Relapsed/Refractory Small Cell Lung Cancer and Select Gynecologic Malignancies
  “Clinical program was discontinued by Novartis” (63% match in meaning)
• Efficacy and Pharmacogenomics of Cladribine Based Salvage Chemotherapy in Patients With Relapse/Refractory and Secondary Acute Myeloid Leukemia (AML) and High Risk Myelodysplastic Syndrome (MDS)
  “No longer have funding support to complete the pharmacogenetics component.” (60% match in meaning)
• Oblimersen Sodium & Combination Chemotherapy in Treating Patients With Newly Diagnosed Diffuse Large B-Cell Lymphoma
  “Manufacturer is no longer making the drug.” (58% match in meaning)
• Phase II Study of Aldesleukin (IL-2) Following the Administration of Zanolimumab (Anti-CD4mAb) in Metastatic Melanoma and Metastatic Renal Cancer
  “The study was terminated because we were not able to obtain the study drug.” (57% match in meaning)
• Muscle, Essential Amino Acids, and eXercise in Heart Failure
  “There is no longer any funding to support the study” (56% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.